Cancer signs and symptoms

Classification	D
External resources	MedlinePlus: 000893;

Cancer signs and symptoms
	Symptoms of cancer can be based on the affected organs
Specialty	Oncology

Cancer symptoms are changes in the body caused by the presence of cancer. They are usually caused by the effect of a cancer on the part of the body where it is growing, although the disease can cause more general symptoms such as weight loss or tiredness. There are more than 100 different types of cancer with a wide range of different signs and symptoms which can manifest in different ways.

Symptoms

Typical symptoms of cancer include:[1][2]

The presence of unusual lump in the body
Changes in a mole on the skin, such as size, color or shape thickness
A persistent cough or hoarseness
A change in bowel habits, such as unusual diarrhea or constipation
Difficulty in swallowing or continuing indigestion
Any abnormal bleeding, including bleeding from the vagina, or blood in urine or faeces
A persistent sore or ulcer
Difficulty passing urine
Unexplained weight loss
Unexplained pain
Unexplained tiredness or fatigue
Skin changes such as an unexplained rash or unusual texture
Unexplained night sweats
Abdominal pain
Unexplainable pains (headaches)

Increased Lactate Production

The Warburg Effect states that cancer cells in the presence of oxygen and glucose take a different path of energy production. Cancer cells are observed to convert glucose in the presence of oxygen into lactate through lactate dehydrogenase instead of traditionally putting pyruvate though the TCA cycle for oxidative phosphorylation.[3] However, cancer cells still carry out oxidative phosphorylation but not primarily for the purpose of energy production but for biomass production through utilizing the intermediates from TCA cycle. This unique metabolism of cancer cells[4] opens doors for possible cancer treatments including targeting lactate dehydrogenase and TCA intermediate production.

gollark: It also depends on aspect ratio, no?

gollark: I think it's JIT-compiled.

gollark: Realistically, it's going to be slow and break somehow on some application(s) people like.

gollark: They apparently have an emulation layer.

gollark: They're moving to ARM, apparently, which is likely to introduce yet more !!FUN!! and eventually locked-down-ness.

References

Possible symptoms of cancer. Cancer Research UK. Retrieved 07 December 2013
"Symptoms of Cancer". WebMD. Retrieved 2016-04-04.
Corbet, Cyril; Feron, Olivier (2017). "Cancer cell metabolism and mitochondria: Nutrient plasticity for TCA cycle fueling". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1868 (1): 7–15. doi:10.1016/j.bbcan.2017.01.002. PMID 28110019.
"Cancer Metabolism". Rafael Pharmaceuticals. Retrieved 2019-12-03.

External links

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] Possible symptoms of cancer. Cancer Research UK. Retrieved 07 December 2013

[2] "Symptoms of Cancer". WebMD. Retrieved 2016-04-04.

[3] Corbet, Cyril; Feron, Olivier (2017). "Cancer cell metabolism and mitochondria: Nutrient plasticity for TCA cycle fueling". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1868 (1): 7–15. doi:10.1016/j.bbcan.2017.01.002. PMID 28110019.

[4] "Cancer Metabolism". Rafael Pharmaceuticals. Retrieved 2019-12-03.