CTP synthase 1

CTP synthase 1 is an enzyme that in human s is encoded by the CTPS gene.[5][6]

CTPS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VO1
Identifiers
Aliases	CTPS1, CTPS, IMD24, CTP synthase 1, GATD5
External IDs	OMIM: 123860 MGI: 1858304 HomoloGene: 20446 GeneCards: CTPS1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 40,979,335 bp[1] End 41,012,565 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 56.52 cM Start 120,539,868 bp[2] End 120,570,276 bp[2]
Gene ontology Molecular function • nucleotide binding • ligase activity • ATP binding • CTP synthase activity • identical protein binding Cellular component • cytosol • membrane • cytoplasm • cytoophidium Biological process • T cell proliferation • B cell proliferation • nucleobase-containing small molecule interconversion • glutamine metabolic process • nucleobase-containing compound metabolic process • 'de novo' CTP biosynthetic process • response to drug • pyrimidine nucleotide biosynthetic process • immune system process • CTP biosynthetic process • pyrimidine nucleobase biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1503	51797
Ensembl	ENSG00000171793	ENSMUSG00000028633
UniProt	P17812	P70698
RefSeq (mRNA)	NM_001301237 NM_001905	NM_016748 NM_001355491
RefSeq (protein)	NP_001288166 NP_001896	NP_058028 NP_001342420
Location (UCSC)	Chr 1: 40.98 – 41.01 Mb	Chr 4: 120.54 – 120.57 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The catalytic conversion of uridine triphosphate (UTP) to cytidine triphosphate (CTP) is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. This enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000171793 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028633 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yamauchi M, Yamauchi N, Phear G, Spurr NK, Martinsson T, Weith A, Meuth M (December 1991). "Genomic organization and chromosomal localization of the human CTP synthetase gene (CTPS)". Genomics. 11 (4): 1088–96. doi:10.1016/0888-7543(91)90036-E. PMID 1783378.
6. "Entrez Gene: CTP synthase".

External links

• Human CTPS1 genome location and CTPS1 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P17812 (CTP synthase 1) at the PDBe-KB.

Further reading

• Thomas PE, Lamb BJ, Chu EH (1988). "Purification of cytidine-triphosphate synthetase from rat liver, and demonstration of monomer, dimer and tetramer" (PDF). Biochim. Biophys. Acta. 953 (3): 334–44. doi:10.1016/0167-4838(88)90042-8. hdl:2027.42/27539. PMID 3355843.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Verschuur AC, Van Gennip AH, Muller EJ, et al. (1999). "Cytidine triphosphate synthase activity and mRNA expression in normal human blood cells". Biol. Chem. 380 (1): 41–6. doi:10.1515/BC.1999.005. PMID 10064135.
• Yamauchi M, Yamauchi N, Meuth M (1990). "Molecular cloning of the human CTP synthetase gene by functional complementation with purified human metaphase chromosomes". EMBO J. 9 (7): 2095–9. doi:10.1002/j.1460-2075.1990.tb07377.x. PMC 551928. PMID 2113467.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Higgins MJ, Loiselle D, Haystead TA, Graves LM (2008). "Human cytidine triphosphate synthetase 1 interacting proteins". Nucleosides Nucleotides Nucleic Acids. 27 (6): 850–7. doi:10.1080/15257770802146502. PMID 18600551.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Higgins MJ, Graves PR, Graves LM (2007). "Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3". J. Biol. Chem. 282 (40): 29493–503. doi:10.1074/jbc.M703948200. PMID 17681942.
• Takahashi E, Yamauchi M, Tsuji H, et al. (1991). "Chromosome mapping of the human cytidine-5'-triphosphate synthetase (CTPS) gene to band 1p34.1-p34.3 by fluorescence in situ hybridization". Hum. Genet. 88 (1): 119–21. doi:10.1007/BF00204942. PMID 1959918.
• Whelan J, Phear G, Yamauchi M, Meuth M (1993). "Clustered base substitutions in CTP synthetase conferring drug resistance in Chinese hamster ovary cells". Nat. Genet. 3 (4): 317–22. doi:10.1038/ng0493-317. PMID 7981751.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gevaert K, Staes A, Van Damme J, et al. (2005). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Han GS, Sreenivas A, Choi MG, et al. (2005). "Expression of Human CTP Synthetase in Saccharomyces cerevisiae Reveals Phosphorylation by Protein Kinase A". J. Biol. Chem. 280 (46): 38328–36. doi:10.1074/jbc.M509622200. PMC 1400552. PMID 16179339.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Chang YF, Martin SS, Baldwin EP, Carman GM (2007). "Phosphorylation of Human CTP Synthetase 1 by Protein Kinase C IDENTIFICATION OF Ser462 AND Thr455 AS MAJOR SITES OF PHOSPHORYLATION". J. Biol. Chem. 282 (24): 17613–22. doi:10.1074/jbc.M702799200. PMC 2081159. PMID 17463002.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.