CTF8

Chromosome transmission fidelity protein 8 homolog is a protein that in humans is encoded by the CHTF8 gene.[5][6]

CHTF8
Identifiers
Aliases	CHTF8, CTF8, DERPC, chromosome transmission fidelity factor 8
External IDs	OMIM: 613202 MGI: 2443370 HomoloGene: 84588 GeneCards: CHTF8
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 69,118,010 bp[1] End 69,132,578 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 106,883,863 bp[2] End 106,893,601 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • DNA clamp loader activity • GO:0043142 single-stranded DNA helicase activity Cellular component • cell nucleus • extracellular exosome • nucleoplasm • Ctf18 RFC-like complex Biological process • mitotic sister chromatid cohesion • DNA replication • cell cycle • positive regulation of DNA-directed DNA polymerase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54921	214987
Ensembl	ENSG00000168802	ENSMUSG00000046691
UniProt	P0CG12 P0CG13	P0CG14 P0CG15
RefSeq (mRNA)	NM_001039690 NM_001040145 NM_001040146 NM_017804	NM_145412 NM_001364186
RefSeq (protein)	NP_001034779 NP_001035236 NP_001034779.1 NP_001035236.1	NP_663387 NP_001351115 NP_663387.3
Location (UCSC)	Chr 16: 69.12 – 69.13 Mb	Chr 8: 106.88 – 106.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair.

This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternative splicing results in multiple variants encoding different isoforms. This gene has a pseudogene on chromosome X.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000168802 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046691 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Merkle CJ, Karnitz LM, Henry-Sanchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". J Biol Chem. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.
6. "Entrez Gene: CTF8 chromosome transmission fidelity factor 8 homolog (S. cerevisiae)".

External links

• Human CHTF8 genome location and CHTF8 gene details page in the UCSC Genome Browser.

Further reading

• Mayer ML, Gygi SP, Aebersold R, Hieter P (2001). "Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae". Mol. Cell. 7 (5): 959–70. doi:10.1016/S1097-2765(01)00254-4. PMID 11389843.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sun M, Ma L, Xu L, et al. (2004). "A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors". Mol. Med. 8 (10): 655–63. PMC 2039945. PMID 12477976.
• Bermudez VP, Maniwa Y, Tappin I, et al. (2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10237–42. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.