CRON-diet

The CRON-diet (Calorie Restriction with Optimal Nutrition)[1] is a nutrient-rich, reduced calorie diet developed by Roy Walford, Lisa Walford, and Brian M. Delaney.[2] The CRON-diet involves calorie restriction in the hope that the practice will improve health and retard aging, while still attempting to provide the recommended daily amounts of various nutrients.[3] Other names include CR-diet, Longevity diet, and Anti-Aging Plan. The Walfords and Delaney, among others, founded the CR Society International to promote the CRON-diet.[4]

Context
Main article: Calorie restriction

There is experimental evidence that calorie restriction can slow biological aging in mammals such as mice and monkeys,[5][6] but the long-term effects in humans remain unknown.[7] The biological mechanisms for the observed effects are not well understood.[8]

Origins
The "Crew Kitchen" inside Biosphere 2

The CRON-diet was developed from data Walford compiled during his participation in Biosphere 2 from 1991 to 1993. The subjects ate a diet low in fat and in calories but "nutrient-dense", derived from the food crops raised inside the Biosphere.[9][10]

Debate on effectiveness

The writer Christopher Turner in The Telegraph reported that Walford claimed that the diet "will retard your rate of ageing, extend lifespan (up to perhaps 150 to 160 years, depending on when you start and how thoroughly you hold to it), and markedly decrease susceptibility to most major diseases."[3] The same article noted however that the diet "failed to dramatically increase Walford's lifespan; he died in 2004 aged 79."[3]

A review of the effects of calorie restriction in humans by Anna Picca and colleagues in 2017 noted that direct evidence was limited to what had been "recorded from the members of the Calorie Restriction Society, who have imposed on themselves a regimen of severe CR with optimal nutrition (CRON), believing to extend in this way their healthy lifespan."[11] The review noted that bone density was reduced but that bone strength was improved and maximal aerobic capacity per unit body mass was maintained or increased, while measures of quality of life including depression and physical function were improved. The review observed that one outcome had been the development of calorie restriction mimetic drugs which would be tested in clinical trials on humans.[11]

Reception

The journalist Pagan Kennedy wrote an opinion piece for The New York Times, mentioning Walford's book The 120 Year Diet and his hope of living for more than 100 years on the CRON diet, noting that instead he died of Lou Gehrig disease at age 79: her piece was titled "The Secret to a Longer Life? Don't Ask These Dead Longevity Researchers".[12]

The journalist Emily Yoffe tried the CRON-diet for Slate. She wrote that Walford had written a book about the diet called Beyond the 120 Year Diet, in which a "typical dinner" consisted of salad, lentils, brown rice, bulgur, a stalk of broccoli, and a glass of skimmed milk.[13][14] Yoffe reported that after more than 2 months on the diet, she had not experienced the promised results: her "very poor" sleep had not improved much; her "energy" remained low; her "foggy mind" was still foggy. But she was pleased that she once again could experience loose-fitting pants.[13]

gollark: This is something where you could probably make it actually-secure-ish through asymmetric cryptography, but just using a symmetric algorithm and hoping nobody will ever dump the keys is moronically stupid.
gollark: Indeed.
gollark: It seems like one of those things which can never actually work as long as someone cares enough to break it.
gollark: I see.
gollark: Or you could end up with a seizure or something because a buffer overflow in some random driver code caused the neural interface to crash in some weird way.

References
  1. CRON-description Archived 2008-02-09 at the Wayback Machine
  2. CRON-diet as a life-extension diet
  3. Turner, Christopher (2010). "The Calorie Restriction dieters". The Telegraph.
  4. "Jan 1993 - Embryonic CR Society". CR Society International. Retrieved 29 July 2019. Brian M. Delaney, President of the CR Society since its early days, was one of several who created the Society. The Society was born in late 1994 when Steven Mehalek (who had the idea to meet), Rupert Hazle, Terry Savery, Lisa Walford, Roy Walford, and Brian M. Delaney got together at meeting of the Academy of Anti-Aging Medicine in Las Vegas.
  5. Omodei, D.; Fontana, L. (6 June 2011). "Very Low Calorie Diet Food Plan". FEBS Letters. 1667 (4): 1537–42. doi:10.1016/j.febslet.2011.03.015. PMC 3439843. PMID 21402069. Archived from the original on June 27, 2019. Retrieved 1 May 2019.
  6. "Can We Prevent Aging?". National Institute on Aging, US National Institutes of Health, Bethesda, MD. 29 July 2016. Archived from the original on 26 September 2016.
  7. Spindler, Stephen R. (2010). "Biological Effects of Calorie Restriction: Implications for Modification of Human Aging". The Future of Aging. pp. 367–438. doi:10.1007/978-90-481-3999-6_12. ISBN 978-90-481-3998-9.
  8. Anderson, R. M.; Shanmuganayagam, D.; Weindruch, R. (2009). "Caloric Restriction and Aging: Studies in Mice and Monkeys". Toxicologic Pathology. 37 (1): 47–51. doi:10.1177/0192623308329476. PMC 3734859. PMID 19075044.
  9. Walford, R. L.; Harris, S. B.; Gunion, M. W. (1992). "The calorically restricted low-fat nutrient-dense diet in Biosphere 2 significantly lowers blood glucose, total leukocyte count, cholesterol, and blood pressure in humans". Proceedings of the National Academy of Sciences of the United States of America. 89 (23): 11533–11537. doi:10.1073/pnas.89.23.11533. PMC 50586. PMID 1454844.
  10. Nagourney, Eric (26 September 2000). "Ups and Downs for Diet Guinea Pigs". The New York Times.
  11. Picca, Anna; Pesce, Vito; Lezza, Angela Maria Serena (2017). "Does eating less make you live longer and better? An update on calorie restriction". Clinical Interventions in Aging. Volume 12: 1887–1902. doi:10.2147/CIA.S126458. ISSN 1178-1998. PMC 5685139. PMID 29184395.
  12. Kennedy, Pagan (9 March 2018). "The Secret to a Longer Life? Don't Ask These Dead Longevity Researchers". The New York Times.
  13. Yoffe, Emily (8 February 2007). "My Starvation Diet". Slate.
  14. Walford, Roy (2000). Beyond the 120-year diet : how to double your vital years. New York: Four Walls Eight Windows. ISBN 978-1-56858-157-6. OCLC 43657044.
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