COMMD3-BMI1

The COMMD3-BMI1 gene in humans encodes the COMMD3-BMI1 readthrough protein. [5]

COMMD3-BMI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H0D, 3RPG, 4R8P
Identifiers
Aliases	COMMD3-BMI1, COMMD3-BMI1 readthrough, BMI1, RNF51, PCGF4
External IDs	MGI: 88174 HomoloGene: 3797 GeneCards: COMMD3-BMI1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p12.2 Start 22,316,388 bp[1] End 22,329,542 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 12.9 cM Start 18,677,018 bp[2] End 18,686,629 bp[2]
Gene ontology Molecular function • promoter-specific chromatin binding • RING-like zinc finger domain binding • metal ion binding • GO:0001948 protein binding • zinc ion binding Cellular component • cytoplasm • ubiquitin ligase complex • nucleoplasm • PRC1 complex • PcG protein complex • cell nucleus • cytosol • nuclear body Biological process • regulation of transcription, DNA-templated • positive regulation of fibroblast proliferation • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • segment specification • negative regulation of gene expression, epigenetic • positive regulation of ubiquitin-protein transferase activity • regulation of gene expression • histone H2A-K119 monoubiquitination • negative regulation of G0 to G1 transition • chromatin organization • haematopoiesis • chromatin silencing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	100532731	12151
Ensembl	ENSG00000269897	ENSMUSG00000026739
UniProt	P35226	P25916
RefSeq (mRNA)	NM_001204062	NM_007552
RefSeq (protein)	NP_001190991 NP_005171	NP_031578
Location (UCSC)	Chr 10: 22.32 – 22.33 Mb	Chr 2: 18.68 – 18.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000269897 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026739 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: COMMD3-BMI1 readthrough". Retrieved 2013-10-05.
6. [provided by RefSeq, Feb 2011].

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.