CNOT3

CCR4-NOT transcription complex subunit 3 is a protein that in humans is encoded by the CNOT3 gene.[5][6][7] It is a subunit of the CCR4-Not deadenylase complex.

CNOT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C0D, 4C0G, 5FU6, 5FU7
Identifiers
Aliases	CNOT3, LENG2, NOT3, NOT3H, CCR4-NOT transcription complex subunit 3, IDDSADF
External IDs	OMIM: 604910 MGI: 2385261 HomoloGene: 133900 GeneCards: CNOT3
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,137,749 bp[1] End 54,155,681 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 3,645,268 bp[2] End 3,661,109 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • CCR4-NOT complex • cytosol • P-body • cell nucleus • CCR4-NOT core complex Biological process • nuclear-transcribed mRNA poly(A) tail shortening • multicellular organism development • gene silencing by RNA • negative regulation of translation • regulation of stem cell population maintenance • regulation of transcription, DNA-templated • trophectodermal cell differentiation • regulation of translation • transcription, DNA-templated • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4849	232791
Ensembl	ENSG00000088038 ENSG00000277600 ENSG00000277114 ENSG00000274616 ENSG00000275979 ENSG00000277615 ENSG00000276082 ENSG00000274176 ENSG00000274941 ENSG00000273943	ENSMUSG00000035632
UniProt	O75175	Q8K0V4
RefSeq (mRNA)	NM_014516	NM_146176
RefSeq (protein)	NP_055331	NP_666288
Location (UCSC)	Chr 19: 54.14 – 54.16 Mb	Chr 7: 3.65 – 3.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CNOT3 has been shown to interact with CNOT8.[5]

References

1. ENSG00000277600, ENSG00000277114, ENSG00000274616, ENSG00000275979, ENSG00000277615, ENSG00000276082, ENSG00000274176, ENSG00000274941, ENSG00000273943 GRCh38: Ensembl release 89: ENSG00000088038, ENSG00000277600, ENSG00000277114, ENSG00000274616, ENSG00000275979, ENSG00000277615, ENSG00000276082, ENSG00000274176, ENSG00000274941, ENSG00000273943 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035632 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (Mar 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
6. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
7. "Entrez Gene: CNOT3 CCR4-NOT transcription complex, subunit 3".

Further reading

• Wende H, Volz A, Ziegler A (2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842.
• Aoki T, Okada N, Wakamatsu T, Tamura TA (2002). "TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3". Biochem. Biophys. Res. Commun. 296 (5): 1097–103. doi:10.1016/S0006-291X(02)02031-4. PMID 12207886.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Yin X, Warner DR, Roberts EA, Pisano MM, Greene RM (2005). "Identification of novel CBP interacting proteins in embryonic orofacial tissue". Biochem. Biophys. Res. Commun. 329 (3): 1010–7. doi:10.1016/j.bbrc.2005.02.075. PMID 15752756.

External links

• Human CNOT3 genome location and CNOT3 gene details page in the UCSC Genome Browser.