CMTM2

CKLF-like MARVEL transmembrane domain-containing protein 2 is a protein that in humans is encoded by the CMTM2 gene.[5]

CMTM2
Identifiers
Aliases	CMTM2, CKLFSF2, CKLF like MARVEL transmembrane domain containing 2
External IDs	OMIM: 607885 MGI: 2447311 HomoloGene: 88915 GeneCards: CMTM2
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 66,579,448 bp[1] End 66,588,275 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 104,322,230 bp[2] End 104,330,764 bp[2]
Gene ontology Molecular function • cytokine activity Cellular component • membrane • extracellular • integral component of membrane Biological process • chemotaxis • regulation of receptor activity • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	146225	75502
Ensembl	ENSG00000140932	ENSMUSG00000035785
UniProt	Q8TAZ6	Q9DAC0
RefSeq (mRNA)	NM_144673 NM_001199317	NM_028524
RefSeq (protein)	NP_001186246 NP_653274	NP_082800
Location (UCSC)	Chr 16: 66.58 – 66.59 Mb	Chr 8: 104.32 – 104.33 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000140932 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035785 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CMTM2 CKLF-like MARVEL transmembrane domain containing 2".

External links

• Human CMTM2 genome location and CMTM2 gene details page in the UCSC Genome Browser.

Further reading

• Liu G, Xin ZC, Chen L, et al. (2007). "Expression and localization of CKLFSF2 in human spermatogenesis". Asian J. Androl. 9 (2): 189–198. doi:10.1111/j.1745-7262.2007.00249.x. PMID 17334588.
• Shi S, Rui M, Han W, et al. (2005). "CKLFSF2 is highly expressed in testis and can be secreted into the seminiferous tubules". Int. J. Biochem. Cell Biol. 37 (8): 1633–1640. doi:10.1016/j.biocel.2004.04.028. PMID 15896670.
• Xu M, Yang S, Gao Y, et al. (2005). "A functional promoter region of the CKLFSF2 gene is located in the last intron/exon region of the upstream CKLFSF1 gene". Int. J. Biochem. Cell Biol. 37 (6): 1296–1307. doi:10.1016/j.biocel.2005.01.004. PMID 15778092.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Han W, Ding P, Xu M, et al. (2004). "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation". Genomics. 81 (6): 609–617. doi:10.1016/S0888-7543(03)00095-8. PMID 12782130.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Denef B, Werf FV, Geest HD, Kesteloot H (1976). "Calibrated apexcardiography and assessment of left ventricular dynamics in man". European journal of cardiology. 4 Suppl: 143–52. PMID 1278213.