SLAMF7

SLAM family member 7 is a protein that in humans is encoded by the SLAMF7 gene.[5][6][7]

SLAMF7
Identifiers
AliasesSLAMF7, 19A, CD319, CRACC, CS1, SLAM family member 7
External IDsOMIM: 606625 MGI: 1922595 HomoloGene: 49660 GeneCards: SLAMF7
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.3Start160,739,057 bp[1]
End160,754,821 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

57823

75345

Ensembl

ENSG00000026751

ENSMUSG00000038179

UniProt

Q9NQ25

Q8BHK6

RefSeq (mRNA)

NM_144539
NM_001347184

RefSeq (protein)

NP_001334113
NP_653122

Location (UCSC)Chr 1: 160.74 – 160.75 MbChr 1: 171.63 – 171.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The surface antigen CD319 (SLAMF7) is a robust marker of normal plasma cells and malignant plasma cells in multiple myeloma. In contrast to CD138 (the traditional plasma cell marker), CD319/SLAMF7 is much more stable and allows robust isolation of malignant plasma cells from delayed or even cryopreserved samples.[8]

Elotuzumab is an antibody that targets this protein.

References

  1. GRCh38: Ensembl release 89: ENSG00000026751 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038179 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Murphy JJ, Hobby P, Vilarino-Varela J, Bishop B, Iordanidou P, Sutton BJ, Norton JD (Feb 2002). "A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion". The Biochemical Journal. 361 (Pt 3): 431–6. doi:10.1042/0264-6021:3610431. PMC 1222324. PMID 11802771.
  6. Boles KS, Mathew PA (Feb 2001). "Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily". Immunogenetics. 52 (3–4): 302–7. doi:10.1007/s002510000274. PMID 11220635.
  7. "Entrez Gene: SLAMF7 SLAM family member 7".
  8. Frigyesi I, Adolfsson J, Ali M, Christophersen MK, Johnsson E, Turesson I, Gullberg U, Hansson M, Nilsson B (Feb 2014). "Robust isolation of malignant plasma cells in multiple myeloma". Blood. 123 (9): 1336–40. doi:10.1182/blood-2013-09-529800. PMID 24385542.

Further reading


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