CBR3

Carbonyl reductase [NADPH] 3 is an enzyme that in humans is encoded by the CBR3 gene.[5][6][7]

CBR3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCBR3, HEL-S-25, SDR21C2, hcarbonyl reductase 3
External IDsOMIM: 603608 MGI: 1309992 HomoloGene: 20332 GeneCards: CBR3
Gene location (Human)
Chr.Chromosome 21 (human)[1]
Band21q22.12Start36,135,079 bp[1]
End36,146,562 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

874

109857

Ensembl

ENSG00000159231

ENSMUSG00000022947

UniProt

O75828

Q8K354

RefSeq (mRNA)

NM_001236

NM_173047

RefSeq (protein)

NP_001227

NP_766635

Location (UCSC)Chr 21: 36.14 – 36.15 MbChr 16: 93.68 – 93.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000159231 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022947 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Watanabe K, Sugawara C, Ono A, Fukuzumi Y, Itakura S, Yamazaki M, Tashiro H, Osoegawa K, Soeda E, Nomura T (May 1999). "Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2". Genomics. 52 (1): 95–100. doi:10.1006/geno.1998.5380. PMID 9740676.
  6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  7. "Entrez Gene: CBR3 carbonyl reductase 3".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.