CBLC

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.[5][6][7]

CBLC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OP0, 3VRN, 3VRO, 3VRP, 3VRQ, 3VRR
Identifiers
Aliases	CBLC, CBL-3, CBL-SL, RNF57, Cbl proto-oncogene C
External IDs	OMIM: 608453 MGI: 1931457 HomoloGene: 8108 GeneCards: CBLC
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 44,777,869 bp[1] End 44,800,652 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 19,778,881 bp[2] End 19,796,809 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SH3 domain binding • phosphotyrosine residue binding • calcium ion binding • epidermal growth factor receptor binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • metal ion binding • ubiquitin-protein transferase activity • transferase activity • receptor tyrosine kinase binding • zinc ion binding • GO:0001948 protein binding Cellular component • cell membrane • membrane raft Biological process • negative regulation of epidermal growth factor-activated receptor activity • cell surface receptor signaling pathway • negative regulation of epidermal growth factor receptor signaling pathway • negative regulation of MAP kinase activity • protein ubiquitination • regulation of signaling • ubiquitin-dependent protein catabolic process • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23624	80794
Ensembl	ENSG00000142273	ENSMUSG00000040525
UniProt	Q9ULV8	Q80XL1
RefSeq (mRNA)	NM_001130852 NM_012116	NM_001161844 NM_023224
RefSeq (protein)	NP_001124324 NP_036248	NP_001155316 NP_075713
Location (UCSC)	Chr 19: 44.78 – 44.8 Mb	Chr 7: 19.78 – 19.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM][7]

Interactions

CBLC has been shown to interact with FYN[8] and Epidermal growth factor receptor.[6][9]

References

1. GRCh38: Ensembl release 89: ENSG00000142273 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040525 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. PMID 10362357.
6. Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Dec 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. PMID 10571044.
7. "Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c".
8. Kim, M; Tezuka T; Suziki Y; Sugano S; Hirai M; Yamamoto T (Oct 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. NETHERLANDS. 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. ISSN 0378-1119. PMID 10571044.
9. Keane, M M; Ettenberg S A; Nau M M; Banerjee P; Cuello M; Penninger J; Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. ENGLAND. 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. ISSN 0950-9232. PMID 10362357.

External links

• Human CBLC genome location and CBLC gene details page in the UCSC Genome Browser.

Further reading

• Ollendorff V, Mattei M, Fournier E, et al. (1999). "A third human CBL gene is on chromosome 19". Int. J. Oncol. 13 (6): 1159–61. doi:10.3892/ijo.13.6.1159. PMID 9824625.
• Irby RB, Mao W, Coppola D, et al. (1999). "Activating SRC mutation in a subset of advanced human colon cancers". Nat. Genet. 21 (2): 187–90. doi:10.1038/5971. PMID 9988270.
• Ettenberg SA, Keane MM, Nau MM, et al. (1999). "Cbl-b inhibits epidermal growth factor receptor signaling". Oncogene. 18 (10): 1855–66. doi:10.1038/sj.onc.1202499. PMID 10086340.
• Loreto MP, Berry DM, McGlade CJ (2002). "Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor Signaling". Mol. Cell. Biol. 22 (12): 4241–55. doi:10.1128/MCB.22.12.4241-4255.2002. PMC 133880. PMID 12024036.
• Szymkiewicz I, Kowanetz K, Soubeyran P, et al. (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". J. Biol. Chem. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
• Courbard JR, Fiore F, Adélaïde J, et al. (2003). "Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH". J. Biol. Chem. 277 (47): 45267–75. doi:10.1074/jbc.M206460200. PMID 12226085.
• Wong ES, Fong CW, Lim J, et al. (2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". EMBO J. 21 (18): 4796–808. doi:10.1093/emboj/cdf493. PMC 126289. PMID 12234920.
• Taher TE, Tjin EP, Beuling EA, et al. (2002). "C-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination". J. Immunol. 169 (7): 3793–800. doi:10.4049/jimmunol.169.7.3793. PMID 12244174.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nau MM, Lipkowitz S (2003). "Comparative genomic organization of the cbl genes". Gene. 308: 103–13. doi:10.1016/S0378-1119(03)00471-2. PMID 12711395.
• Kim M, Tezuka T, Tanaka K, Yamamoto T (2004). "Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation". Oncogene. 23 (9): 1645–55. doi:10.1038/sj.onc.1207298. PMID 14661060.
• Kassenbrock CK, Anderson SM (2004). "Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations". J. Biol. Chem. 279 (27): 28017–27. doi:10.1074/jbc.M404114200. PMID 15117950.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.