CTU2

CTU2 (formerly known as C16orf84) is a human gene located on chromosome 16.[5] The mRNA encodes the longer isoform. The gene encodes a cytoplasmic protein that plays a probable role in tRNA modification.[6]

CTU2
Identifiers
Aliases	CTU2, C16orf84, NCS2, UPF0432, cytosolic thiouridylase subunit 2, MFRG
External IDs	OMIM: 617057 MGI: 1914215 HomoloGene: 79815 GeneCards: CTU2
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.3 Start 88,706,483 bp[1] End 88,715,396 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 122,476,143 bp[2] End 122,484,138 bp[2]
Gene ontology Molecular function • tRNA binding • GO:0001948 protein binding • sulfurtransferase activity • nucleotidyltransferase activity Cellular component • cytoplasm • cytosol • macromolecular complex Biological process • tRNA wobble uridine modification • tRNA thio-modification • tRNA processing • tRNA wobble position uridine thiolation • protein urmylation • tRNA modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	348180	66965
Ensembl	ENSG00000174177	ENSMUSG00000049482
UniProt	Q2VPK5	Q3U308
RefSeq (mRNA)	NM_001012759 NM_001012762 NM_001318507 NM_001318513	NM_153775
RefSeq (protein)	NP_001012777 NP_001012780 NP_001305436 NP_001305442	NP_722470
Location (UCSC)	Chr 16: 88.71 – 88.72 Mb	Chr 8: 122.48 – 122.48 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000174177 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049482 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: C16orf84".
6. "NCBI protein: cytoplasmic tRNA 2-thiolation protein 2 isoform 1".

External links

• Human CTU2 genome location and CTU2 gene details page in the UCSC Genome Browser.

Further reading

• Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL (November 2008). "A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway". Proc. Natl. Acad. Sci. U.S.A. 105 (47): 18255–60. Bibcode:2008PNAS..10518255S. doi:10.1073/pnas.0808756105. PMC 2584574. PMID 19017811.
• Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP (August 2008). "A quantitative atlas of mitotic phosphorylation". Proc. Natl. Acad. Sci. U.S.A. 105 (31): 10762–7. Bibcode:2008PNAS..10510762D. doi:10.1073/pnas.0805139105. PMC 2504835. PMID 18669648.