Butyramide
Butyramide is the amide of butyric acid. It has the molecular formula C3H7CONH2. It is a white solid that freely soluble in water and ethanol, but slightly soluble in diethyl ether. At room temperature, butyramide is a crystalline solid and in contrast to butyric acid, it is devoid of unpleasant, rancid smell.
![]() | |
![]() | |
Names | |
---|---|
IUPAC name
Butanamide | |
Other names
Butyramide n-Butylamide | |
Identifiers | |
3D model (JSmol) |
|
ChEBI | |
ChemSpider | |
DrugBank | |
ECHA InfoCard | 100.007.980 |
PubChem CID |
|
UNII | |
CompTox Dashboard (EPA) |
|
| |
| |
Properties | |
C4H9NO | |
Molar mass | 87.122 g·mol−1 |
Density | 1.03 g/cm3 |
Melting point | 115 to 116 °C (239 to 241 °F; 388 to 389 K) |
Boiling point | 216 °C (421 °F; 489 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
![]() ![]() ![]() | |
Infobox references | |
Synthesis
Butyramide can be synthesized by:
- catalytic hydration of butyronitrile;
- reaction of butyryl chloride with ammonium salts;
- reduction of butyraldoxime.
Derivatives
Some of its derivatives have shown preliminary strong anticonvulsive activity and inhibitory action on histone deacetylases, crucial enzymes controlling the proliferative or differentiation status of most cells.
gollark: To be fair, the Android one is generally bad.
gollark: And yet somewhat insecure.
gollark: As planned.
gollark: ```osmarks@fenrir ~> lsblkNAME MAJ:MIN RM SIZE RO TYPE MOUNTPOINTsda 8:0 0 111.8G 0 disk ├─sda1 8:1 0 1G 0 part /boot└─sda2 8:2 0 110.8G 0 part └─cryptlvm 254:0 0 110.8G 0 crypt ├─arch-swap 254:1 0 6G 0 lvm [SWAP] └─arch-root 254:2 0 104.8G 0 lvm /```
gollark: Well, yes, but I slightly improved that recently.
See also
References
- Merck Index, 11th Edition, 1592
- Jiang J et al. PLos One 2012; 7(3): e34283
- Liu WH et al. Yao Xue Xue Bao 2012 Feb; 47(2): 194-99.
- Vitorivic-Todorovic MD et al. Bioorg Med Chem 2010 Feb; 18(3): 1181-93.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.