Bundle branches

The bundle branches, or Tawara branches,[1] are offshoots of the bundle of His in the heart's ventricle. They play an integral role in the electrical conduction system of the heart by transmitting cardiac action potentials from the bundle of His to the Purkinje fibers.[2]

Bundle branches
The left bundle branch (4) and the right bundle branch (10)
Anatomical terminology

Structure

There are two branches of the bundle of His: the left bundle branch and the right bundle branch, both of which are located along the interventricular septum. The left bundle branch further divides into the left anterior fascicles and the left posterior fascicles. These structures lead to a network of thin filaments known as Purkinje fibers. They play an integral role in the electrical conduction system of the heart by transmitting cardiac action potentials to the Purkinje fibers.[2]

Clinical significance

When a bundle branch or fascicle becomes injured (by underlying heart disease, myocardial infarction, or cardiac surgery), it may cease to conduct electrical impulses appropriately, resulting in altered pathways for ventricular depolarization. This condition is known as a bundle branch block.[3]

History

The bundle branches were separately described by Retzer and Braeunig as early as 1904, but their physiological function remained unclear and their role in the electrical conduction system of the heart remained unknown until Sunao Tawara published his monograph on Das Reizleitungssystem des Säugetierherzens (English: The Conduction System of the Mammalian Heart) in 1906.[4] Although Tawara's monograph had demonstrated that the branches of the bundle of His may transmit cardiac action potentials to the ventricles, the functional proof for his observation was not provided until 1910, when Hans Eppinger and Carl Julius Rothberger showed that cutting off both branches to induce a bilateral bundle branch block results in a complete heart block.[5]

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References
  1. Kullmann T, Baráth Z, Csiszér E (January 2009). "Remission of left Tawara-branch block under treatment for systemic sarcoidosis". International Journal of Cardiology. 131 (2): e83–4. doi:10.1016/j.ijcard.2007.07.063. PMID 17935802.
  2. Tusscher KH, Panfilov AV (2008). "Modelling of the ventricular conduction system". Progress in Biophysics and Molecular Biology. 96 (1–3): 152–70. doi:10.1016/j.pbiomolbio.2007.07.026. PMID 17910889.
  3. Kumar V, Venkataraman R, Aljaroudi W, et al. (January 2013). "Implications of left bundle branch block in patient treatment". The American Journal of Cardiology. 111 (2): 291–300. doi:10.1016/j.amjcard.2012.09.029. PMID 23111137.
  4. Silverman ME, Grove D, Upshaw CB (June 2006). "Why does the heart beat? The discovery of the electrical system of the heart". Circulation. 113 (23): 2775–81. doi:10.1161/CIRCULATIONAHA.106.616771. PMID 16769927.
  5. Hollman A (1985). "The history of bundle branch block". Medical History Supplement (5): 82–102. PMC 2557404. PMID 3915526.

Further reading
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