Bacoside A

Bacoside A is a mixture of chemical compounds, known as bacosides, isolated from Bacopa monnieri.[1] Its major constituents include the saponins bacoside A3, bacopaside II, jujubogenin isomer of bacopasaponin C, and bacopasaponin C.[2][3] The mixture has been studied in in vitro experiments and animal models for its potential neuroprotectivity.[4][5][6][7][8][9][10][11]

Chemical structure of bacoside A3, a major constituent of bacoside A

References
  1. Majumdar; et al. (2013). "Bacosides and Neuroprotection". Natural Products: 3639–3660. doi:10.1007/978-3-642-22144-6_157. ISBN 978-3-642-22143-9.
  2. M. Deepak; G. K. Sangli; P. C. Arun; A. Amit (January–February 2005). "Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC". Phytochemical Analysis. 16 (1): 24–29. doi:10.1002/pca.805. PMID 15688952.
  3. "Bacoside A, mixture of Bacoside A3, Bacopaside II, Bacopaside X and Bacopasaponin C". Sigma-Aldrich.
  4. Thomas, RB; Joy, S; Ajayan, MS; Paulose, CS (2013). "Neuroprotective Potential of Bacopa monnieri and Bacoside a Against Dopamine Receptor Dysfunction in the Cerebral Cortex of Neonatal Hypoglycaemic Rats". Cellular and Molecular Neurobiology. 33 (8): 1065–74. doi:10.1007/s10571-013-9973-0. PMID 23975094.
  5. Russo; Borrelli (2005). "Bacopa monniera, a reputed nootropic plant: an overview". Phytomedicine. 12 (4): 305–317. doi:10.1016/j.phymed.2003.12.008. PMID 15898709.
  6. Aguiar and Borowski, 2013. Neuropharmacological Review of the Nootropic Herb Bacopa monnieri. Rejuvenation Research. http://online.liebertpub.com/doi/abs/10.1089/rej.2013.1431
  7. Bhattacharya, SK; Bhattacharya, A; Kumar, A; Ghosal, S (2000). "Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus". Phytother Res. 14 (3): 174–179. doi:10.1002/(sici)1099-1573(200005)14:3<174::aid-ptr624>3.0.co;2-o.
  8. Anbarasi, K; Vani, G; Balakrishna, K; Devi, CS (2006). "Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats". Life Sci. 78 (12): 1378–1384. doi:10.1016/j.lfs.2005.07.030. PMID 16226278.
  9. Anbarasi, K; Sabitha, KE; Devi, CS (2005). "Lactate dehydrogenase isoenzyme patterns upon chronic exposure to cigarette smoke: protective effect of bacoside A.". Environ Toxicol Pharmacol. 20 (2): 345–350. doi:10.1016/j.etap.2005.03.006. PMID 21783610.
  10. Vohora, D; Pal, SN; Pillai, KK (2000). "Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant". J Ethnopharmacol. 71 (3): 383–390. doi:10.1016/s0378-8741(99)00213-5.
  11. Hota, SK; Barhwal, K; Baitharu, I; Prasad, D; Singh, SB; Ilavazhagan, G (2009). "Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment". Neurobiol Dis. 34 (1): 23–39. doi:10.1016/j.nbd.2008.12.006. PMID 19154788.


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