Bacopaside

Bacopasides are triterpene saponins isolated from Bacopa monnieri.

Members of this class of compounds include:

  • Bacopaside I, shows antidepressant-like effects in a mouse model[1]
  • Bacopaside II[2]
  • Bacopaside III[3][4]
  • Bacopaside IV[4]
  • Bacopaside V[4]
  • Bacopaside VI[5]
  • Bacopaside VII[5]
  • Bacopaside VIII[5]
  • Bacopaside IX[6]
  • Bacopaside X[6]
  • Bacopaside XI, shows nootropic activity in a mouse model[6]

References
  1. Liu, X; Liu, F; Yue, R; Li, Y; Zhang, J; Wang, S; Zhang, S; Wang, R; Shan, L; Zhang, W (2013). "The antidepressant-like effect of bacopaside I: Possible involvement of the oxidative stress system and the noradrenergic system". Pharmacology Biochemistry and Behavior. 110: 224–30. doi:10.1016/j.pbb.2013.07.007. PMID 23872136.
  2. Chakravarty, AK; Sarkar, T; Masuda, K; Shiojima, K; Nakane, T; Kawahara, N (2001). "Bacopaside I and II: Two pseudojujubogenin glycosides from Bacopa monniera". Phytochemistry. 58 (4): 553–6. doi:10.1016/S0031-9422(01)00275-8. PMID 11576596.
  3. Hou, CC; Lin, SJ; Cheng, JT; Hsu, FL (2002). "Bacopaside III, bacopasaponin G, and bacopasides A, B, and C from Bacopa monniera". Journal of Natural Products. 65 (12): 1759–63. doi:10.1021/np020238w. PMID 12502309.
  4. Chakravarty, AK; Garai, S; Masuda, K; Nakane, T; Kawahara, N (2003). "Bacopasides III-V: Three new triterpenoid glycosides from Bacopa monniera". Chemical & Pharmaceutical Bulletin. 51 (2): 215–7. doi:10.1248/cpb.51.215. PMID 12576661.
  5. Zhou, Y; Shen, YH; Zhang, C; Su, J; Liu, RH; Zhang, WD (2007). "Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models". Journal of Natural Products. 70 (4): 652–5. doi:10.1021/np060470s. PMID 17343408.
  6. Zhou, Y; Peng, L; Zhang, WD; Kong, DY (2009). "Effect of triterpenoid saponins from Bacopa monniera on scopolamine-induced memory impairment in mice". Planta Medica. 75 (6): 568–74. doi:10.1055/s-0029-1185339. PMID 19214943.


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