BCAR3

Breast cancer anti-estrogen resistance protein 3 is a protein that in humans is encoded by the BCAR3 gene.[5][6]

BCAR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T6A
Identifiers
Aliases	BCAR3, NSP2, SH2D3B, breast cancer anti-estrogen resistance 3, AND-34, NSP family adaptor protein, BCAR3 adaptor protein, NSP family member
External IDs	OMIM: 604704 MGI: 1352501 HomoloGene: 31181 GeneCards: BCAR3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.1 Start 93,561,741 bp[1] End 93,847,150 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G1 Start 122,294,136 bp[2] End 122,530,191 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • guanyl-nucleotide exchange factor activity Cellular component • intracellular Biological process • small GTPase mediated signal transduction • lens morphogenesis in camera-type eye • response to drug • signal transduction • positive regulation of peptidyl-serine phosphorylation • positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8412	29815
Ensembl	ENSG00000137936	ENSMUSG00000028121
UniProt	O75815	Q9QZK2
RefSeq (mRNA)	NM_001261408 NM_001261409 NM_001261410 NM_001308251 NM_003567	NM_013867 NM_001355264
RefSeq (protein)	NP_001248337 NP_001248338 NP_001248339 NP_001295180 NP_003558	NP_038895 NP_001342193
Location (UCSC)	Chr 1: 93.56 – 93.85 Mb	Chr 3: 122.29 – 122.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hallmark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000137936 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028121 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. van Agthoven T, van Agthoven TL, Dekker A, van der Spek PJ, Vreede L, Dorssers LC (Jul 1998). "Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells". EMBO J. 17 (10): 2799–808. doi:10.1093/emboj/17.10.2799. PMC 1170620. PMID 9582273.
6. "Entrez Gene: BCAR3 breast cancer anti-estrogen resistance 3".

External links

• Human BCAR3 genome location and BCAR3 gene details page in the UCSC Genome Browser.

Further reading

• Dorssers LC, van Agthoven T (1997). "Genetic mechanisms of estrogen-independence in breast cancer". Pathol. Res. Pract. 192 (7): 743–51. doi:10.1016/S0344-0338(96)80096-3. PMID 8880875.
• Johnston SR (1998). "Acquired tamoxifen resistance in human breast cancer--potential mechanisms and clinical implications". Anticancer Drugs. 8 (10): 911–30. doi:10.1097/00001813-199711000-00002. PMID 9436634.
• Lu Y, Brush J, Stewart TA (1999). "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway". J. Biol. Chem. 274 (15): 10047–52. doi:10.1074/jbc.274.15.10047. PMID 10187783.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cai D, Felekkis KN, Near RI, et al. (2003). "The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42". J. Immunol. 170 (2): 969–78. doi:10.4049/jimmunol.170.2.969. PMID 12517963.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dorssers LC, van Agthoven T, Brinkman A, et al. (2006). "Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway". Breast Cancer Res. 7 (1): R82–92. doi:10.1186/bcr954. PMC 1064102. PMID 15642172.
• Felekkis KN, Narsimhan RP, Near R, et al. (2005). "AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner". Mol. Cancer Res. 3 (1): 32–41. PMID 15671247.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Vervoort VS, Roselli S, Oshima RG, Pasquale EB (2007). "Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling". Gene. 391 (1–2): 161–70. doi:10.1016/j.gene.2006.12.016. PMC 1876674. PMID 17270363.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Near RI, Zhang Y, Makkinje A, et al. (2007). "AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology". J. Cell. Physiol. 212 (3): 655–65. doi:10.1002/jcp.21059. PMC 2640322. PMID 17427198.
• Schrecengost RS, Riggins RB, Thomas KS, et al. (2007). "Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling". Cancer Res. 67 (13): 6174–82. doi:10.1158/0008-5472.CAN-06-3455. PMC 4109708. PMID 17616674.