Anchoring fibrils

Anchoring fibrils (composed largely of type VII collagen) extend from the basal lamina of epithelial cells and attach to the lamina reticularis (also known as the reticular lamina) by wrapping around the reticular fiber (collagen III) bundles. The basal lamina and lamina reticularis together make up the basement membrane. Anchoring fibrils are essential to the functional integrity of the dermoepidermal junction.

Epidermolysis bullosa dystrophica

Epidermolysis bullosa dystrophica, also known as Dystrophic EB (DEB) is a chronic skin condition caused when anchoring fibrils are abnormal, diminished, or absent. This causes a weak dermoepidermal junction, where the epidermis easily separates from the dermis causing much pain. This condition is caused by a mutation of COL7A1, the gene that codes for a type of collagen 7.

gollark: This also has the problem that you need the same production on each end anyway.
gollark: Also, with actual mod support it might be somewhat more immersive and might be more automatable.
gollark: e. g. computers with data, slightly damaged tools, enchanted stuff
gollark: Or at least can't be easily transferred.
gollark: And that's not really the same - firstly, prices will probably not be identical due to various factors, and secondly some stuff can't be transferred that way.

See also

References
  • Regauer, S.; Seiler, GR; Barrandon, Y; Easley, KW; Compton, CC (1990). "Epithelial origin of cutaneous anchoring fibrils". The Journal of Cell Biology. 111 (5): 2109–15. doi:10.1083/jcb.111.5.2109. PMC 2116344. PMID 2229187.
  • Keene, Douglas R.; Sakai, Lynn Y.; Lunstrum, Gregory P.; Morris, Nicholas P.; Burgeson, Robert E. (1987). "Type VII collagen forms an extended network of anchoring fibrils". The Journal of Cell Biology. 104 (3): 611–21. doi:10.1083/jcb.104.3.611. PMC 2114566. PMID 3818794.
  • Bruckner-Tuderman, Leena; Höpfner, Bianca; Hammami-Hauasli, Nadja (1999). "Biology of anchoring fibrils: Lessons from dystrophic epidermolysis bullosa". Matrix Biology. 18 (1): 43–54. doi:10.1016/S0945-053X(98)00007-9. PMID 10367730.
  • Burgeson, Robert E. (1993). "Type VII Collagen, Anchoring Fibrils, and Epidermolysis Bullosa". Journal of Investigative Dermatology. 101 (3): 252–5. doi:10.1111/1523-1747.ep12365129. PMID 8370960.
  • McGrath, John A.; Ishida-Yamamoto, Akemi; O'Grady, Anthony; Leigh, Irene M.; Eady, Robin A. J. (1993). "Structural Variations in Anchoring Fibrils in Dystrophic Epidermolysis Bullosa: Correlation with Type VII Collagen Expression". Journal of Investigative Dermatology. 100 (4): 366–72. doi:10.1111/1523-1747.ep12471830. PMID 8454899.
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