Anchoring fibrils

Anchoring fibrils (composed largely of type VII collagen) extend from the basal lamina of epithelial cells and attach to the lamina reticularis (also known as the reticular lamina) by wrapping around the reticular fiber (collagen III) bundles. The basal lamina and lamina reticularis together make up the basement membrane. Anchoring fibrils are essential to the functional integrity of the dermoepidermal junction.

Epidermolysis bullosa dystrophica

Epidermolysis bullosa dystrophica, also known as Dystrophic EB (DEB) is a chronic skin condition caused when anchoring fibrils are abnormal, diminished, or absent. This causes a weak dermoepidermal junction, where the epidermis easily separates from the dermis causing much pain. This condition is caused by a mutation of COL7A1, the gene that codes for a type of collagen 7.

gollark: It is, at least, kind of funny.
gollark: Also they're entirely reliant on the city for electricity and water and stuff.
gollark: Context: you can't really grow food on tiny bits of soil on cardboard. You can't really grow much food on the tiny plots. You can't grow food fast enough for it to be useful in your "commune" in the middle of a city. You probably can't grow enough food *at all* in that area to feed the sort of population density cities typically have. You definitely can't really do it without much farming equipment and by just making a few tiny soil bits with plants in them.
gollark: Yes, exactly.
gollark: https://twitter.com/tweetbrettmac/status/1270983562226012161?s=12

See also

References
  • Regauer, S.; Seiler, GR; Barrandon, Y; Easley, KW; Compton, CC (1990). "Epithelial origin of cutaneous anchoring fibrils". The Journal of Cell Biology. 111 (5): 2109–15. doi:10.1083/jcb.111.5.2109. PMC 2116344. PMID 2229187.
  • Keene, Douglas R.; Sakai, Lynn Y.; Lunstrum, Gregory P.; Morris, Nicholas P.; Burgeson, Robert E. (1987). "Type VII collagen forms an extended network of anchoring fibrils". The Journal of Cell Biology. 104 (3): 611–21. doi:10.1083/jcb.104.3.611. PMC 2114566. PMID 3818794.
  • Bruckner-Tuderman, Leena; Höpfner, Bianca; Hammami-Hauasli, Nadja (1999). "Biology of anchoring fibrils: Lessons from dystrophic epidermolysis bullosa". Matrix Biology. 18 (1): 43–54. doi:10.1016/S0945-053X(98)00007-9. PMID 10367730.
  • Burgeson, Robert E. (1993). "Type VII Collagen, Anchoring Fibrils, and Epidermolysis Bullosa". Journal of Investigative Dermatology. 101 (3): 252–5. doi:10.1111/1523-1747.ep12365129. PMID 8370960.
  • McGrath, John A.; Ishida-Yamamoto, Akemi; O'Grady, Anthony; Leigh, Irene M.; Eady, Robin A. J. (1993). "Structural Variations in Anchoring Fibrils in Dystrophic Epidermolysis Bullosa: Correlation with Type VII Collagen Expression". Journal of Investigative Dermatology. 100 (4): 366–72. doi:10.1111/1523-1747.ep12471830. PMID 8454899.
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