ATP5H

The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase.[5][6]

ATP5PD
Identifiers
Aliases	ATP5PD, ATPQ, ATP synthase, H+ transporting, mitochondrial Fo complex subunit D, ATP5H, ATP synthase peripheral stalk subunit d, APT5H
External IDs	OMIM: 618121 MGI: 1918929 HomoloGene: 130552 GeneCards: ATP5PD
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 75,038,863 bp[1] End 75,046,985 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 115,415,689 bp[2] End 115,419,962 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ATPase activity • GO:0022891 transmembrane transporter activity • hydrogen ion transmembrane transporter activity • proton-transporting ATP synthase activity, rotational mechanism • GO:0001948 protein binding • GO:0032403 macromolecular complex binding Cellular component • mitochondrial inner membrane • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) • mitochondrial proton-transporting ATP synthase complex • mitochondrion • extracellular exosome • membrane • nucleoplasm • proton-transporting ATP synthase complex, coupling factor F(o) • mitochondrial proton-transporting ATP synthase, stator stalk • cytosol Biological process • mitochondrial ATP synthesis coupled proton transport • ion transport • ATP synthesis coupled proton transport • ATP biosynthetic process • cristae formation • transport • ATP metabolic process • cellular response to peptide Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10476	71679
Ensembl	ENSG00000167863	ENSMUSG00000034566
UniProt	O75947	Q9DCX2
RefSeq (mRNA)	NM_006356 NM_001003785	NM_027862
RefSeq (protein)	NP_001003785 NP_006347	NP_082138
Location (UCSC)	Chr 17: 75.04 – 75.05 Mb	Chr 11: 115.42 – 115.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

ATP synthase D chain, mitochondrial
Identifiers
Symbol	ATP5H
Pfam	PF05873
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F₁, and the membrane-spanning component, F₀, which comprises the proton channel. The F₁ complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F_o seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the F_o complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000167863 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034566 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
6. "Entrez Gene: ATP5PD ATP synthase peripheral stalk subunit d".

External links

• Human ATP5PD genome location and ATP5PD gene details page in the UCSC Genome Browser.

Further reading

• Kinosita K, Yasuda R, Noji H (2003). "F1-ATPase: a highly efficient rotary ATP machine". Essays Biochem. 35: 3–18. doi:10.1042/bse0350003. PMID 12471886.
• Oster G, Wang H (2003). "Rotary protein motors". Trends Cell Biol. 13 (3): 114–21. doi:10.1016/S0962-8924(03)00004-7. PMID 12628343.
• Leyva JA, Bianchet MA, Amzel LM (2003). "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)". Mol. Membr. Biol. 20 (1): 27–33. doi:10.1080/0968768031000066532. PMID 12745923.
• Higuti T, Kuroiwa K, Miyazaki S, et al. (1994). "The complete amino acid sequence of subunit d of rat liver mitochondrial H(+)-ATP synthase". J. Biochem. 114 (5): 714–7. PMID 7509337.
• Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. doi:10.1038/35185. PMID 9461222.
• Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. doi:10.1038/24409. PMID 9834036.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Cross RL (2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. doi:10.1038/427407b. PMID 14749816.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.