ASF1B

Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene.[5][6][7]

ASF1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5BNX, 5BO0
Identifiers
Aliases	ASF1B, CIA-II, anti-silencing function 1B histone chaperone
External IDs	OMIM: 609190 MGI: 1914179 HomoloGene: 56797 GeneCards: ASF1B
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 14,119,512 bp[1] End 14,136,613 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C2 Start 83,955,507 bp[2] End 83,970,197 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • histone binding • GO:0001948 protein binding Cellular component • nuclear chromatin • chromatin • cell nucleus • nucleoplasm • macromolecular complex Biological process • multicellular organism development • DNA replication-dependent nucleosome assembly • nucleosome assembly • DNA replication-independent nucleosome assembly • cell differentiation • regulation of transcription, DNA-templated • chromatin assembly or disassembly • transcription, DNA-templated • spermatogenesis • chromatin organization • blastocyst hatching Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55723	66929
Ensembl	ENSG00000105011 ENSG00000288210	ENSMUSG00000005470
UniProt	Q9NVP2	Q9DAP7
RefSeq (mRNA)	NM_018154	NM_024184
RefSeq (protein)	NP_060624	NP_077146
Location (UCSC)	Chr 19: 14.12 – 14.14 Mb	Chr 8: 83.96 – 83.97 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.[7]

Interactions

ASF1B has been shown to interact with TLK2,[6][8] CHAF1B,[5][8] TLK1[6][8] and CHAF1A.[5][8]

References

1. ENSG00000288210 GRCh38: Ensembl release 89: ENSG00000105011, ENSG00000288210 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005470 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056. PMID 11897662.
6. Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068–73. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414.
7. "Entrez Gene: ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae)".
8. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

• Loyola A, Almouzni G (Mar 2004). "Histone chaperones, a supporting role in the limelight". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1677 (1–3): 3–11. doi:10.1016/j.bbaexp.2003.09.012. PMID 15020040.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Umehara T, Horikoshi M (Sep 2003). "Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis". The Journal of Biological Chemistry. 278 (37): 35660–7. doi:10.1074/jbc.M303549200. PMID 12842904.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Groth A, Ray-Gallet D, Quivy JP, Lukas J, Bartek J, Almouzni G (Jan 2005). "Human Asf1 regulates the flow of S phase histones during replicational stress". Molecular Cell. 17 (2): 301–11. doi:10.1016/j.molcel.2004.12.018. PMID 15664198.
• Sen SP, De Benedetti A (2006). "TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1". BMC Molecular Biology. 7: 37. doi:10.1186/1471-2199-7-37. PMC 1626478. PMID 17054786.
• Hayashi R, Goto Y, Tanaka R, Oonogi K, Hisasue M, Yoshida K (Feb 2007). "Transcriptional regulation of human chromatin assembly factor ASF1". DNA and Cell Biology. 26 (2): 91–9. doi:10.1089/dna.2006.0515. PMID 17328667.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• Human ASF1B genome location and ASF1B gene details page in the UCSC Genome Browser.