ARFIP2

Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene.[5][6][7]

ARFIP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I49, 1I4D, 1I4L, 1I4T, 4DCN
Identifiers
Aliases	ARFIP2, POR1, ADP ribosylation factor interacting protein 2
External IDs	OMIM: 601638 MGI: 1924182 HomoloGene: 8234 GeneCards: ARFIP2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 6,474,683 bp[1] End 6,481,479 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 105,634,203 bp[2] End 105,640,416 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Rac GTPase binding • phosphatidylinositol-4-phosphate binding • protein domain specific binding • GO:0001948 protein binding • GTP binding • identical protein binding • cadherin binding • GTP-dependent protein binding • phospholipid binding Cellular component • cell cortex • trans-Golgi network membrane • cell membrane • ruffle • cytosol • cytoplasm Biological process • ruffle organization • small GTPase mediated signal transduction • actin cytoskeleton organization • regulation of Arp2/3 complex-mediated actin nucleation • lamellipodium assembly • intracellular protein transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23647	76932
Ensembl	ENSG00000132254	ENSMUSG00000030881
UniProt	P53365	Q8K221
RefSeq (mRNA)	NM_001242854 NM_001242855 NM_001242856 NM_012402	NM_029802
RefSeq (protein)	NP_001229783 NP_001229784 NP_001229785 NP_036534 NP_001357335 NP_001357337 NP_001357338 NP_001357340 NP_001357341 NP_001357342 NP_001363487 NP_001363488 NP_001363489 NP_001363490 NP_001363491 NP_001363492 NP_001363493	NP_084078
Location (UCSC)	Chr 11: 6.47 – 6.48 Mb	Chr 7: 105.63 – 105.64 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ARFIP2 has been shown to interact with Arf6,[8][9] ARF3,[6] ARF5[6][9] and RAC1.[5][9][10]

References

1. GRCh38: Ensembl release 89: ENSG00000132254 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030881 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Van Aelst L, Joneson T, Bar-Sagi D (August 1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15): 3778–86. PMC 452058. PMID 8670882.
6. Kanoh H, Williger BT, Exton JH (February 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
7. "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)".
8. D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
9. Shin OH, Exton JH (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
10. Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (May 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801.

Further reading

• D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
• Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (May 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801.
• Shin OH, Exton JH (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
• Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C (March 2002). "Arfaptin 2 regulates the aggregation of mutant huntingtin protein". Nature Cell Biology. 4 (3): 240–5. doi:10.1038/ncb761. PMID 11854752.
• Lu L, Hong W (September 2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Molecular Biology of the Cell. 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
• Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S (June 2005). "Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment". The Journal of Biological Chemistry. 280 (23): 22021–8. doi:10.1074/jbc.M407528200. PMID 15809304.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

External links

• Human ARFIP2 genome location and ARFIP2 gene details page in the UCSC Genome Browser.