ARFGEF1

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.[5][6][7]

ARFGEF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LTL, 5EE5
Identifiers
Aliases	ARFGEF1, ARFGEP1, BIG1, P200, ADP ribosylation factor guanine nucleotide exchange factor 1
External IDs	OMIM: 604141 MGI: 2442988 HomoloGene: 4687 GeneCards: ARFGEF1
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q13.2 Start 67,173,511 bp[1] End 67,343,781 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A2 Start 10,137,571 bp[2] End 10,232,670 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • guanyl-nucleotide exchange factor activity • ARF guanyl-nucleotide exchange factor activity • myosin binding • GO:0001948 protein binding • protein kinase A regulatory subunit binding Cellular component • cytosol • Golgi apparatus • membrane • nuclear matrix • Golgi membrane • nucleoplasm • trans-Golgi network • nucleolus • small nuclear ribonucleoprotein complex • perinuclear region of cytoplasm • cell nucleus • cytoplasm Biological process • endomembrane system organization • positive regulation of protein kinase B signaling • negative regulation of actin filament polymerization • Golgi organization • positive regulation of wound healing • regulation of ARF protein signal transduction • positive regulation of protein glycosylation in Golgi • GO:0034259 negative regulation of GTPase activity • protein transport • neuron projection development • regulation of establishment of cell polarity • exocytosis • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10565	211673
Ensembl	ENSG00000066777	ENSMUSG00000067851
UniProt	Q9Y6D6	G3X9K3
RefSeq (mRNA)	NM_006421	NM_001102430
RefSeq (protein)	NP_006412	NP_001095900
Location (UCSC)	Chr 8: 67.17 – 67.34 Mb	Chr 1: 10.14 – 10.23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.[7]

Interactions

ARFGEF1 has been shown to interact with FKBP2,[8] ARFGEF2[9] and PRKAR1A.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000066777 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067851 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry. 274 (18): 12308–15. doi:10.1074/jbc.274.18.12308. PMID 10212200.
6. Morinaga N, Tsai SC, Moss J, Vaughan M (Nov 1996). "Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain". Proceedings of the National Academy of Sciences of the United States of America. 93 (23): 12856–60. doi:10.1073/pnas.93.23.12856. PMC 24010. PMID 8917509.
7. "Entrez Gene: ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)".
8. Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M (Mar 2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2322–7. doi:10.1073/pnas.2628047100. PMC 151339. PMID 12606707.
9. Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. doi:10.1073/pnas.97.6.2567. PMC 15969. PMID 10716990.
10. Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. doi:10.1073/pnas.0337678100. PMC 149883. PMID 12571360.

External links

• Human ARFGEF1 genome location and ARFGEF1 gene details page in the UCSC Genome Browser.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Mansour SJ, Skaug J, Zhao XH, Giordano J, Scherer SW, Melançon P (Jul 1999). "p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A". Proceedings of the National Academy of Sciences of the United States of America. 96 (14): 7968–73. doi:10.1073/pnas.96.14.7968. PMC 22171. PMID 10393931.
• Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. doi:10.1073/pnas.97.6.2567. PMC 15969. PMID 10716990.
• Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members". Genomics. 69 (1): 113–9. doi:10.1006/geno.2000.6310. PMID 11013081.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (Jan 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M (Mar 2004). "Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". Proceedings of the National Academy of Sciences of the United States of America. 101 (9): 2752–7. doi:10.1073/pnas.0307345101. PMC 365693. PMID 14973189.
• Saeki N, Tokuo H, Ikebe M (Mar 2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity". The Journal of Biological Chemistry. 280 (11): 10128–34. doi:10.1074/jbc.M413415200. PMID 15644318.
• Citterio C, Jones HD, Pacheco-Rodriguez G, Islam A, Moss J, Vaughan M (Feb 2006). "Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei". Proceedings of the National Academy of Sciences of the United States of America. 103 (8): 2683–8. doi:10.1073/pnas.0510571103. PMC 1413798. PMID 16467138.
• Belov GA, Altan-Bonnet N, Kovtunovych G, Jackson CL, Lippincott-Schwartz J, Ehrenfeld E (Jan 2007). "Hijacking components of the cellular secretory pathway for replication of poliovirus RNA". Journal of Virology. 81 (2): 558–67. doi:10.1128/JVI.01820-06. PMC 1797456. PMID 17079330.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Shen X, Hong MS, Moss J, Vaughan M (Jan 2007). "BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1". Proceedings of the National Academy of Sciences of the United States of America. 104 (4): 1230–5. doi:10.1073/pnas.0610535104. PMC 1783117. PMID 17227842.
• Kuroda F, Moss J, Vaughan M (Feb 2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma". Proceedings of the National Academy of Sciences of the United States of America. 104 (9): 3201–6. doi:10.1073/pnas.0611696104. PMC 1805514. PMID 17360629.