AKAP8L

A-kinase anchor protein 8-like is a protein that in humans is encoded by the AKAP8L gene.[5][6][7]

AKAP8L
Identifiers
Aliases	AKAP8L, HA95, HAP95, NAKAP, NAKAP95, A-kinase anchoring protein 8 like
External IDs	OMIM: 609475 MGI: 1860606 HomoloGene: 8658 GeneCards: AKAP8L
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 15,380,050 bp[1] End 15,419,141 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 32,321,424 bp[2] End 32,350,607 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • lamin binding • histone deacetylase binding • DEAD/H-box RNA helicase binding • DNA binding • GO:0001948 protein binding • RNA binding • protein kinase A regulatory subunit binding Cellular component • nuclear matrix • chromatin • nuclear speck • PML body • cell nucleus • cytoplasm • ribonucleoprotein Biological process • positive regulation of histone deacetylation • nuclear envelope disassembly • regulation of mRNA export from nucleus • mitotic chromosome condensation • cell cycle G2/M phase transition • positive regulation of transcription from RNA polymerase II promoter • regulation of histone phosphorylation • transcription, DNA-templated • regulation of transcription, DNA-templated • RNA splicing • mRNA processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26993	54194
Ensembl	ENSG00000011243	ENSMUSG00000002625
UniProt	Q9ULX6	Q9R0L7
RefSeq (mRNA)	NM_001291478 NM_014371	NM_017476
RefSeq (protein)	NP_001278407 NP_055186	n/a
Location (UCSC)	Chr 19: 15.38 – 15.42 Mb	Chr 17: 32.32 – 32.35 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

AKAP8L has been shown to interact with:

• DHX9,[5][8] and
• Thymopoietin.[9][10]

References

1. GRCh38: Ensembl release 89: ENSG00000011243 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002625 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F (Jul 2000). "A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element". The Journal of Biological Chemistry. 275 (28): 21396–21401. doi:10.1074/jbc.M909887199. PMID 10748171.
6. Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skålhegg BS (Jan 2000). "Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95". Biology of the Cell. 92 (1): 27–37. doi:10.1016/S0248-4900(00)88761-4. PMID 10761695.
7. "Entrez Gene: AKAP8L A kinase (PRKA) anchor protein 8-like".
8. Yang JP, Tang H, Reddy TR, Wong-Staal F (Aug 2001). "Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses". The Journal of Biological Chemistry. 276 (33): 30694–700. doi:10.1074/jbc.M102809200. PMID 11402034.
9. Martins SB, Eide T, Steen RL, Jahnsen T, Skålhegg BS, Collas P (Nov 2000). "HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics". Journal of Cell Science. 113 Pt 21: 3703–13. PMID 11034899.
10. Martins S, Eikvar S, Furukawa K, Collas P (Jan 2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". The Journal of Cell Biology. 160 (2): 177–88. doi:10.1083/jcb.200210026. PMC 2172640. PMID 12538639.

External links

• Human AKAP8L genome location and AKAP8L gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Dec 1998). "Selection system for genes encoding nuclear-targeted proteins". Nature Biotechnology. 16 (13): 1338–1342. doi:10.1038/4315. PMID 9853615.
• Seki N, Ueki N, Yano K, Saito T, Masuho Y, Muramatsu M (2000). "cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region". Journal of Human Genetics. 45 (1): 0031–0037. doi:10.1007/s100380070040. PMID 10697960.
• Yang JP, Tang H, Reddy TR, Wong-Staal F (Aug 2001). "Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses". The Journal of Biological Chemistry. 276 (33): 30694–30700. doi:10.1074/jbc.M102809200. PMID 11402034.
• Wistow G, Bernstein SL, Ray S, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Molecular Vision. 8: 185–95. PMID 12107412.
• Martins S, Eikvar S, Furukawa K, Collas P (Jan 2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". The Journal of Cell Biology. 160 (2): 177–188. doi:10.1083/jcb.200210026. PMC 2172640. PMID 12538639.
• Martins SB, Marstad A, Collas P (Sep 2003). "In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling". Biochemistry. 42 (35): 10456–10461. doi:10.1021/bi0350699. PMID 12950172.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
• Sayer JA, Manczak M, Akileswaran L, Reddy PH, Coghlan VM (2006). "Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis". Neuromolecular Medicine. 7 (4): 297–310. doi:10.1385/NMM:7:4:297. PMID 16391387.