AIM-HIGH trial

AIM-HIGH was a multi-center clinical trial related to the prophylactic treatment coronary artery disease involving some 90 sites in the United States and Canada, which was conducted between 2006 and 2012 and involved 3,414 volunteers [1].

AIM-HIGH was an acronym for Atherothrombosis Intervention in Metabolic Syndrome with low HDL/HIGH Triglycerides trial[2]

Description

The trial was designed to test whether adding high dose, extended-release niacin to simvastatin may be a better than statin therapy alone in reducing long-term cardiovascular events. The participants, who all had a history of cardiovascular disease, were selected according to the following profile: [3]

Results

The trial was stopped early because there was a demonstrable lack of efficacy for this intervention. The addition of high dose, extended release niacin to a statin did increase HDL cholesterol, as expected, but did not reduce cardiovascular events. The analysis also showed that there was little to no probability that adding high-dose, extended release niacin to statin treatment would show a benefit even if the study continued to its originally planned completion.

gollark: See? BEE LIFESPANS.
gollark: ++remind 2y-2🐝
gollark: The negative timedeltas thing was a great idea without flaw utterly.
gollark: ++remind 3d-2h <@319753218592866315> make macron <@!330678593904443393>
gollark: As a new mRNA strand is generated by the action of the RNA polymerase II machinery on a stretch of DNA, it gets a “cap” attached to the end that’s coming out from the DNA (the “5-prime” end), a special nucleotide (7-methylguanosine) that’s used just for that purpose. But don’t get the idea that the new mRNA strand is just waving in the nucleoplasmic breeze – at all points, the developing mRNA is associated with a whole mound of specialized RNA-binding proteins that keep it from balling up on itself like a long strand of packing tape, which is what it would certainly end up doing otherwise.

References
  1. National Heart Lung & Blood Institute (USA) Questions and Answers: AIM-HIGH Study, May 26, 2011
  2. Healio Cardiology Review of AIM-HIGH trial
  3. New England Journal of Medicine 2018-09-17 pp 2255 - 2267


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