2,4-dienoyl-CoA reductase 1

2,4-dienoyl-CoA reductase 1 is a protein that in humans is encoded by the DECR1 gene. [5]

DECR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W6U, 1W73, 1W8D
Identifiers
Aliases	DECR1, DECR, NADPH, SDR18C1, 2,4-dienoyl-CoA reductase 1, mitochondrial, 2,4-dienoyl-CoA reductase 1
External IDs	OMIM: 222745 MGI: 1914710 HomoloGene: 68178 GeneCards: DECR1
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.3 Start 90,001,405 bp[1] End 90,053,633 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A2 Start 15,917,240 bp[2] End 15,945,507 bp[2]
Gene ontology Molecular function • oxidoreductase activity, acting on NAD(P)H • oxidoreductase activity • 2,4-dienoyl-CoA reductase (NADPH) activity • NADPH binding Cellular component • mitochondrial matrix • extracellular exosome • mitochondrion • cell nucleus • nucleoplasm • cytosol Biological process • fatty acid beta-oxidation • oxidation-reduction process • protein homotetramerization • fatty acid metabolic process • lipid metabolism • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1666	67460
Ensembl	ENSG00000104325	ENSMUSG00000028223
UniProt	Q16698	Q9CQ62
RefSeq (mRNA)	NM_001359 NM_001330575	NM_026172
RefSeq (protein)	NP_001317504 NP_001350	NP_080448
Location (UCSC)	Chr 8: 90 – 90.05 Mb	Chr 4: 15.92 – 15.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters.

See also

• DECR2

References

1. GRCh38: Ensembl release 89: ENSG00000104325 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028223 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: 2,4-dienoyl-CoA reductase 1". Retrieved 2017-09-12.

Further reading

• Alphey MS, Yu W, Byres E, Li D, Hunter WN (2005). "Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site". J. Biol. Chem. 280 (4): 3068–77. doi:10.1074/jbc.M411069200. PMID 15531764.
• Yu W, Chu X, Chen G, Li D (2005). "Studies of human mitochondrial 2,4-dienoyl-CoA reductase". Arch. Biochem. Biophys. 434 (1): 195–200. doi:10.1016/j.abb.2004.10.018. PMID 15629123.
• Rosenzweig SD (2008). "Inflammatory manifestations in chronic granulomatous disease (CGD)". J. Clin. Immunol. 28 Suppl 1: S67–72. doi:10.1007/s10875-007-9160-5. PMID 18193341.
• Kardon T, Senesi S, Marcolongo P, Legeza B, Bánhegyi G, Mandl J, Fulceri R, Benedetti A (2008). "Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes". FEBS Lett. 582 (13): 1809–15. doi:10.1016/j.febslet.2008.04.045. PMID 18472006.
• Mizuta I, Tsunoda T, Satake W, Nakabayashi Y, Watanabe M, Takeda A, Hasegawa K, Nakashima K, Yamamoto M, Hattori N, Murata M, Toda T (2008). "Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease". Hum. Genet. 124 (1): 89–94. doi:10.1007/s00439-008-0525-5. PMID 18568448.
• Moe KT, Woon FP, De Silva DA, Wong P, Koh TH, Kingwell B, Chin-Dusting J, Wong MC (2008). "Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population". Eur. J. Neurol. 15 (12): 1309–14. doi:10.1111/j.1468-1331.2008.02308.x. PMID 19049547.
• Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q (2009). "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity". Occup Environ Med. 66 (12): 848–53. doi:10.1136/oem.2008.044024. PMC 2928224. PMID 19773279.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLoS ONE. 5 (9): e12862. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.