DECR2

Peroxisomal 2,4-dienoyl-CoA reductase is an enzyme that in humans is encoded by the DECR2 gene.[5][6][7]

DECR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4FC6, 4FC7
Identifiers
Aliases	DECR2, PDCR, SDR17C1, 2,4-dienoyl-CoA reductase 2, peroxisomal, 2,4-dienoyl-CoA reductase 2
External IDs	OMIM: 615839 MGI: 1347059 HomoloGene: 22223 GeneCards: DECR2
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 401,858 bp[1] End 412,487 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 13.06 cM Start 26,081,208 bp[2] End 26,090,337 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity • receptor binding • 2,4-dienoyl-CoA reductase (NADPH) activity • trans-2-enoyl-CoA reductase (NADPH) activity Cellular component • peroxisomal membrane • peroxisome • cytosol Biological process • unsaturated fatty acid biosynthetic process • oxidation-reduction process • fatty acid metabolic process • lipid metabolism • fatty acid beta-oxidation using acyl-CoA oxidase • protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26063	26378
Ensembl	ENSG00000242612 ENSG00000274296	ENSMUSG00000036775
UniProt	Q9NUI1	Q9WV68
RefSeq (mRNA)	NM_020664	NM_011933
RefSeq (protein)	NP_065715	NP_036063
Location (UCSC)	Chr 16: 0.4 – 0.41 Mb	Chr 17: 26.08 – 26.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. ENSG00000274296 GRCh38: Ensembl release 89: ENSG00000242612, ENSG00000274296 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036775 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. De Nys K, Meyhi E, Mannaerts GP, Fransen M, Van Veldhoven PP (Aug 2001). "Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase". Biochim Biophys Acta. 1533 (1): 66–72. doi:10.1016/s1388-1981(01)00141-x. PMID 11514237.
6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
7. "Entrez Gene: DECR2 2,4-dienoyl CoA reductase 2, peroxisomal".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.