10-Deacetylbaccatin
10-Deacetylbaccatins are a series of closely related natural organic compounds isolated from the yew tree (Genera Taxus). 10-Deacetylbaccatin III is a precursor to the anti-cancer drug docetaxel (Taxotere).
Names | |
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IUPAC name
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one | |
Other names
10-Deacetylbaccatin III 10-Deacetylbaccatine III | |
Identifiers | |
3D model (JSmol) |
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.128.614 |
PubChem CID |
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UNII | |
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Properties | |
C29H36O10 | |
Molar mass | 544.59 g/mol |
Appearance | colorless solid |
Melting point | 234 °C (453 °F; 507 K) |
insoluble | |
Solubility | soluble in methanol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
10-deacetylbaccatin III 10-O-acetyltransferase converts 10-deacetylbaccatin to baccatin III:
- acetyl-CoA + 10-deacetylbaccatin III ⇌ CoA + baccatin III
External links
- CID 6712096 from PubChem - 7-Epi-10-Deacetylbaccatin III
- CID 9872117 from PubChem - 10-Deacetylbaccatin V
- CID 5316348 from PubChem - 10-Deacetylbaccatin VI
- CID 5317065 from PubChem - 13-Epi-10-Deacetylbaccatin III
- CID 15957452 from PubChem - 13-[3-(2-Naphthyl)prop-2-enoyl]-2-debenzoyl-2-(4-methoxybenzoxyl)-10-deacetylbaccatin III
- CID 15957458 from PubChem - 10-N,N-Dimethylglycyl-13-[3-(2-Naphthyl)prop-2-enoyl]-10-deacetylbaccatin III
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