I think you can use audit for specific file/directory or you can write custom rule based on your requirement
auditctl -w <path to the file you need to monitor> -p war -k test
Where -w is for specifying file path
-p is for permission access (read,write,execute and attribute change)
-k key name,you can give name you can use to filter audit rule
Then you can search it using
ausearch -ts today -k test
For eg I used this,create this file /tmp/test and then write some random data
auditctl -w /tmp/test -p warx -k test
and then execute this command
ausearch -ts today -k test
--ts for start date
-k is for key string
So the output of this
type=SYSCALL msg=audit(1407949301.821:63216): arch=c000003e syscall=191 success=no
exit=-61 a0=eacca0 a1=3600005db7 a2=7fff15265180 a3=84 items=1 ppid=2384 pid=16921
auid=0 uid=0 gid=0 euid=0 suid=0 fsuid=0 egid=0 sgid=0 fsgid=0 tty=pts0 ses=10096
comm="vim" exe="/usr/bin/vim" key="test"
So if you check the last line of output it will show command executed is vim and with uid=0 which is root
If you want to make these changes persistent across reboot,inside /etc/audit/audit.rules add the entry like this
-w /tmp/test -p warx -k test
and make sure auditd service is up and running
service auditd status
For more info you can refer http://www.cyberciti.biz/tips/linux-audit-files-to-see-who-made-changes-to-a-file.html