We think that the price difference is way too big (the price/bay is more than triple). Why is this?
The price difference is a function of the capabilities of the product. As @TomTom said, multiple paths, zoning, power supplies, and hot-swap components are all features of a high-end JBOD storage enclosure.
Now, I would suggest that building a server today with a large amount of local storage requires some research and understanding of the implications of that design.
Can you elaborate a bit on why you need 45-60 disks in one enclosure?
Is this for storage capacity? IOPS requirements/performance? Do you need 2.5" disks or 3.5" disks?
There was a time when it made sense to do something like this... especially if there was some form of replication or application-level resiliency. This was when servers like the Sun x4540 were popular. But if this is a standalone server, I'd go with a head unit (2U server) and cascade one or more JBOD enclosures via SAS to arrive at the required capacity. More modular, safer design, less risk of the entire setup dying. The disks should probably be SAS as well... but that's another discussion.