I have a Virtual Machine (in ESXi 5.1) running Ubuntu Server 12.04. When I try to boot my system I grub2 tells me "error: unknown filesystem". I've tried booting a Live CD then reinstalling grub from both a chrooted environment and by supplying the --root-directory option. I've even tried a boot-repair CD (results here) and reinstalling grub. Whatever I use to fix it, I'm getting the error "Path `/boot/grub' is not readable by GRUB on boot. Installation is impossible. Aborting."
To complicate things I'm running a RAID5 array (5 disks) using mdadm and btrfs for my filesystem. The btrfs tools that ship with Ubuntu 12.04 are really old. I've added ppa:cjwatson/grub (currently grub2 ver 2.00-2) and ppa:yofel/btrfs (currently btrfs-tools ver. 0.20~git20130524~650e656-0daily13) to my software sources to get more up to date utilities, with no help. The system was previously working before switching from a 4 disk RAID0 setup. I think this may have been the first reboot since the upgrade, but it was running fine for weeks using RAID5.