I have a windows 2008 dev/testing server setup for testing web apps. I just installed ibm client access (v6r1m0) and after my reboot my sites now get a 503 service unavailable error.
My application pools will not start and I get the following in the application logs: The worker process for application pool 'ASP.NET v4.0' encountered an error 'Cannot read configuration file due to insufficient permissions ' trying to read global module configuration data from file '\?\C:\Windows\Microsoft.NET\Framework64\v4.0.30319\CONFIG\machine.config', line number '0'. Worker process startup aborted.
I had everything working just fine until the ibm install.
I am very grateful to anyone that can help out this developer swimming in unfamiliar waters.