Honestly, I'd hold off on ext4 right now for production use.
There are other options if you're running into real performance problems with the filesystem (and I can understand that situation, at my last job we had performance limitations in an application due to ext3). Depending on your chosen distribution, you might be able to use jfs, xfs, or reiserfs. All three will generally outperform ext3 in different ways, and all three are much more tested and stable than ext4 right now.
So, my recommendation would be multiple parts. First, investigate thoroughly to make sure you're optimizing in the right place. Test your application on different filesystems and ensure that the performance is improved enough to make a filesystem change valid.
Also, depending on your application, adding more RAM might improve performance. Linux, by default, will make use of any RAM that isn't committed to applications as disk cache. Sometimes having a few GB of "unused" RAM can have a significant performance increase on boxes with heavy disk activity.
Finally, what's your timeline requirement here? If ext3 wasn't cutting it and I had to build a machine with a different filesystem today, I'd probably use xfs or jfs. If I could push it off for 6-8 months, I'd probably wait and see how ext4 has shaped up.