For what it's worth, here is my advice:
Don't use a PC as a server. Neither the hardware nor the OS is suitable for the job. If that office is always going to be small, get yourself a smallish tower server and a license for Windows Small Business Server. If the office is going to get larger over time or is a satellite office to a larger company, then consider a normal Windows Server 2008 Edition with half a dozen client access licenses (CALs). You will need DHCP and DNS: these can be provided by the server or by your gateway device (read more below).
For access from home, I would recommend OpenVPN. There is a Windows appliance available from here, you can use self-generated keys and the clients work like a charm (there are clients for Linux, Windows and Max OS X). We have several dozen people on it, and I never hear anything about it. It just works. We use keys and the clients build a SSL tunnel to the office network. That's effectively the same security you have on a HTTPS website. As far as I know OpenVPN also supports IPSec/IKE tunnels, if you prefer that.
For backups I would probably use bacula, but that's because I am mainly a Linux man. There are tons of suitable packages. The most important thing is that the backups are automated and that you have off-site backups. This can be done by spooling the backups onto a USB drive and taking the drive home, or multiple USB drives (I am trying to come up with solutions that won't cost you an arm and a leg). If money is not a problem, go for a small tape drive in the tower server.
Now for some more general advice. A lot of small companies set up their internal LAN on 192.168.0.x/24, because that's sort of the default. Don't do that. Use any other number, such as 192.168.10.0/24 or 192.168.13.0/24. Makes life a lot easier when you have to connect to supplier/customer networks, as most likely they are not using the same IP range and you don't have to do any fancy footwork with NAT.
Get yourself a decent switch. Doesn't have to be fully managed, but if you can afford to spend around £200, you already get switches with web interface, for monitoring, and fault detection.
Use decent quality cable and connectors. Or insist on them if contractors do the wiring. And make them check out every single connection. I have spent hours doing fault finding on new cabling, only to find out that the contractors used lousy hardware or got their wiring schemes mixed up.
Rather use 1 good quality networked printer than half a dozen cheap ones. You'll have much less trouble that way. Plus: you actually get to enjoy lower print costs, since the cost per page on the bigger printers is generally better. My personal favourite is HP, but Xerox and Brother also make very decent printers. Stay away from Lexmark, nothing but trouble.
Spend a bit of money on a decent gateway device that does firewall, routing, and the like. NO need to spend hundreds of pounds there, but don't use the cheap shit from PCWorld and the likes, that stuff is made for SOHO, but in reality it breaks if you keep it running 24/7/365. For around £100 pound you can get some decent stuff. If you are happy to explore other avenues, you could use a Linux box and put smoothwall or monowall on it (but don't do that if you are not comfortable with Linux).
Can't think of more, but I am sure you have questions. Just fire away.