Villainous/YMMV

• Demonic Spider: The Atomic Tower. It has massive range, massive area damage, and can damage your monsters harder than anything in the game. Nothing can stop the damage once its launched. Not to mention how powerful it gets in latter waves... Thankfully, the missiles can be tricked by clever monster placement and can be stunned like any other tower in the game and has a low fire rate (0.10 shots per second meaning a shot every ten seconds).
• Goddamn Bats: Arguably, the Bog Towers and Holy Towers due to their percent-based damage.