Shin Megami Tensei III: Nocturne/Nightmare Fuel

• Humanity dies in a flash of light as the Conception begins. That flash of light, followed by the Magatsuhi flowing out from buildings you see before Tokyo wraps itself up into a ball? That's humanity being wiped out in the blink of an eye without a fighting chance! And you can only watch.
• The moment when the Young Boy drops the wriggling, bug-like Magatama on your eye, and it burrows into your brain? That'll do it.
• Kabukicho Prison. Just...Kabukicho Prison. It's an abandoned building filled with empty rooms, some of which have voices from nowhere. And then the Mirage flips the building, turns everything white, except for the streaks of blood on the ceiling, and the giant, golden shutters. Behind most of those shutters are jail cells/torture chambers filled with Manikins.
• The Reveal as to the true identity of Hijiri.