Life with Derek/Funny

• A lot of stuff involving the character of Ralph, but the best moment involving him would have to be during "Cheerleader Casey", where puts on an In A World/SUNDAY! SUNDAY! SUNDAY!-style voiceover voice. skip to 9:09 to hear it, and then to see the other actors reactions in a blooper real, skip to 2:31.
• In Vacation With Derek, Derek's line "GIMME THOSE KEYS!!!". Not a funny like by itself, but the delivery is priceless.
• Olga, the Russian Driving instructor in "Driving Lessons", particularly Casey's reaction to finding out she actually exists, despite thinking blowing Derek off about it before.