Full Moon o Sagashite/Tear Jerker

All of Full Moon o Sagashite, from start to finish.

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• Specific moments occur in episode 42, where, after becoming an Idol Singer, overcoming hardships and traveling to America to find him, Mitsuki finds that her childhood friend Eichi died a year and a half ago. This is either better or worse in the manga, in which Eichi died in a plane crash and Mitsuki knew from the very beginning that he was dead, but was in serious denial and became Full Moon to find him anyway.
• Then, of course, there's the last episode, where This Troper cried in despair for the first half and in happiness for the second.
• Izumi's backstory in the manga where we find out that he killed himself when he was six standing in a railroad crossing, because he felt that his mother didn't want him. It turns out that his mother let him go because she felt like she wasn't able to love him.