From Hell/YMMV

In the comic miniseries:

• Nausea Fuel: Some sections are hard to get through, due to the intense combination of Eddie Campbell's artwork and Moore's disturbing subject matter. It even made Neil "Scary Trousers" Gaiman (Master of Modern Horror) feel a little queasy.^[1]
• Nightmare Fuel: By the truckload. Every murder is shown and described in graphic detail. Gull himself becomes an in-universe Nightmare Fuel Station Attendant, inspiring both Dr. Jekyll and Mr. Hyde and William Blake's The Ghost of a Flea
• The Woobie: The chapter isn't called The Unfortunate Mr Druitt for nothing.

In the movie:

• Adaptation Displacement: Most people had never heard of the comics before the movie was released.
  • Also, the movie is a fairly straightforward whodunnit film, whereas the in the comic, the Ripper's identity is known throughout (though considering Ian Holm's very recognisable voice, this holds for the film too), and concerns itself with the "why" rather than the "who."
• Alternate Character Interpretation: In the end, is Abberline's death from opium overdose just an accident or does he kill himself because he can't ever see Mary again.
• Tear Jerker: "I'm a queen! A queen!"

1. ↑ To elaborate - Alan Moore once gleefully detailed the method of murder and organ removal to Neil Gaiman, who had to step outside to get some air so he wouldn't vomit. Twice.