Casshern Sins/Tear Jerker

• A lot of the later episodes fall into this category... but oh, God, the final episode. Ohji's death for one. But then Lyuze's death is so, so much worse.
• Hell, even many of the earlier episodes qualify. In a show full of endearing one-shot characters that rarely survive to the end of the episode, you're guaranteed at least one moment per episode.
• Dune's death. He finally found Luna again, only for her to treat him like dirt and refuse to even be there for him as he's dying. No wonder Casshern is furious at her right afterwards.
• The final ED, with every member of the cast sans Casshern lying around sleeping, becomes a lot more depressing when almost everyone in it is dead.