CSF2RB

CSF2RB (also known as cytokine receptor common subunit beta) is a common subunit to the following type I cytokine receptors:

  • GM-CSF receptor
  • IL-3 receptor
  • IL-5 receptor.[5]
CSF2RB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCSF2RB, CD131, CDw131, IL3RB, IL5RB, SMDP5, colony stimulating factor 2 receptor beta common subunit, betaGMR, colony stimulating factor 2 receptor subunit beta
External IDsOMIM: 138981 MGI: 1339760 HomoloGene: 339 GeneCards: CSF2RB
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q12.3Start36,913,628 bp[1]
End36,940,439 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

1439

12984

Ensembl

ENSG00000100368

ENSMUSG00000071714

UniProt

P32927

P26954

RefSeq (mRNA)

NM_000395

NM_001287389
NM_007781

RefSeq (protein)

NP_000386

NP_001274318
NP_031807

Location (UCSC)Chr 22: 36.91 – 36.94 MbChr 15: 78.28 – 78.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000100368 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000071714 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". The EMBO Journal. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.
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