Zinc finger protein 516

Zinc finger protein 516 is a protein that in humans is encoded by the ZNF516 gene.[5]

ZNF516
Identifiers
Aliases	ZNF516, HsT287, zinc finger protein 516
External IDs	OMIM: 615114 MGI: 2443957 HomoloGene: 37122 GeneCards: ZNF516
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q23 Start 76,357,682 bp[1] End 76,495,242 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E3 Start 82,910,663 bp[2] End 83,005,314 bp[2]
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • DNA binding • GO:0001158 core promoter proximal region sequence-specific DNA binding • activating transcription factor binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • multicellular organism development • positive regulation of transcription, DNA-templated • response to cold • adipose tissue development • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • signal transduction • brown fat cell differentiation • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9658	329003
Ensembl	ENSG00000101493	ENSMUSG00000058881
UniProt	Q92618	Q7TSH3
RefSeq (mRNA)	NM_014643	NM_001177464 NM_183033
RefSeq (protein)	NP_055458	NP_001170935 NP_898854
Location (UCSC)	Chr 18: 76.36 – 76.5 Mb	Chr 18: 82.91 – 83.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the Krüppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation.

References

1. GRCh38: Ensembl release 89: ENSG00000101493 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058881 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger protein 516".

Further reading

• Shaffer JR, Feingold E, Wang X, Lee M, Tcuenco K, Weeks DE, Weyant RJ, Crout R, McNeil DW, Marazita ML (January 2013). "GWAS of dental caries patterns in the permanent dentition". Journal of Dental Research. 92 (1): 38–44. doi:10.1177/0022034512463579. PMC 3521449. PMID 23064961.
• Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y (April 2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature. 422 (6933): 735–8. doi:10.1038/nature01550. PMID 12700765.
• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Lee MG, Wynder C, Cooch N, Shiekhattar R (September 2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation". Nature. 437 (7057): 432–5. doi:10.1038/nature04021. PMID 16079794.
• Yashin AI, Wu D, Arbeev KG, Ukraintseva SV (September 2010). "Joint influence of small-effect genetic variants on human longevity". Aging. 2 (9): 612–20. doi:10.18632/aging.100191. PMC 2984609. PMID 20834067.
• O'Brien RP, Phelan PJ, Conroy J, O'Kelly P, Green A, Keogan M, O'Neill D, Jennings S, Traynor C, Casey J, McCormack M, Conroy R, Chubb A, Ennis S, Shields DC, Cavalleri GL, Conlon PJ (2013). "A genome-wide association study of recipient genotype and medium-term kidney allograft function". Clinical Transplantation. 27 (3): 379–87. doi:10.1111/ctr.12093. PMID 23432519.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.