Zinc finger protein 398

Zinc finger protein 398 is a protein that in humans is encoded by the ZNF398 gene. [5]

ZNF398
Identifiers
Aliases	ZNF398, P51, P71, ZER6, zinc finger protein 398
External IDs	MGI: 1917856 HomoloGene: 12358 GeneCards: ZNF398
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.1 Start 149,126,416 bp[1] End 149,183,042 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B2.3 Start 47,835,661 bp[2] End 47,873,537 bp[2]
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • intracellular • cell nucleus Biological process • positive regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57541	272347
Ensembl	ENSG00000197024	ENSMUSG00000062519
UniProt	Q8TD17	n/a
RefSeq (mRNA)	NM_020781 NM_170686	NM_027477 NM_173034
RefSeq (protein)	NP_065832 NP_733787	n/a
Location (UCSC)	Chr 7: 149.13 – 149.18 Mb	Chr 6: 47.84 – 47.87 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described, but their full length sequence has not been determined.

References

1. GRCh38: Ensembl release 89: ENSG00000197024 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062519 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger protein 398". Retrieved 2016-02-29.

Further reading

• Conroy AT, Sharma M, Holtz AE, Wu C, Sun Z, Weigel RJ (2002). "A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha". J. Biol. Chem. 277 (11): 9326–34. doi:10.1074/jbc.M107702200. PMID 11779858.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.