ZBTB1

Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.[5]

ZBTB1
Identifiers
AliasesZBTB1, ZNF909, zinc finger and BTB domain containing 1
External IDsOMIM: 616578 MGI: 2442326 HomoloGene: 8974 GeneCards: ZBTB1
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q23.3Start64,503,712 bp[1]
End64,533,690 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

22890

268564

Ensembl

ENSG00000126804

ENSMUSG00000033454

UniProt

Q9Y2K1

Q91VL9

RefSeq (mRNA)

NM_001123329
NM_014950

NM_178744
NM_001364323

RefSeq (protein)

NP_001116801
NP_055765

NP_848859
NP_001351252

Location (UCSC)Chr 14: 64.5 – 64.53 MbChr 12: 76.37 – 76.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ZBTB1 is essential for the development of lymphocytes in mice: T cells are absent from ZBTB1 mutant mice, and numbers of B cells and natural killer cells are reduced.[6][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000126804 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033454 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Zinc finger and BTB domain containing 1".
  6. Siggs OM, Li X, Xia Y, Beutler B (January 2012). "ZBTB1 is a determinant of lymphoid development". The Journal of Experimental Medicine. 209 (1): 19–27. doi:10.1084/jem.20112084. PMC 3260866. PMID 22201126.
  7. Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM (August 2012). "Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development". Journal of Immunology. 189 (3): 1253–64. doi:10.4049/jimmunol.1200623. PMC 3401355. PMID 22753936.
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