WBP4

WW domain-binding protein 4 is a protein that in humans is encoded by the WBP4 gene.[5][6]

WBP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DK1, 2JXW
Identifiers
Aliases	WBP4, FBP21, WW domain binding protein 4
External IDs	OMIM: 604981 MGI: 109568 HomoloGene: 38287 GeneCards: WBP4
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.11 Start 41,061,509 bp[1] End 41,084,006 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 79,459,937 bp[2] End 79,481,520 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • zinc ion binding • proline-rich region binding • GO:0001948 protein binding • metal ion binding • nucleic acid binding Cellular component • nuclear speck • spliceosomal complex • nucleoplasm • cell nucleus • U2-type precatalytic spliceosome Biological process • mRNA cis splicing, via spliceosome • mRNA processing • RNA splicing • mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11193	22380
Ensembl	ENSG00000120688	ENSMUSG00000022023
UniProt	O75554	Q61048
RefSeq (mRNA)	NM_007187	NM_018765
RefSeq (protein)	NP_009118	NP_061235
Location (UCSC)	Chr 13: 41.06 – 41.08 Mb	Chr 14: 79.46 – 79.48 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000120688 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022023 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bedford MT, Reed R, Leder P (Sep 1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif". Proc Natl Acad Sci U S A. 95 (18): 10602–7. doi:10.1073/pnas.95.18.10602. PMC 27941. PMID 9724750.
6. "Entrez Gene: WBP4 WW domain binding protein 4 (formin binding protein 21)".

Further reading

• Takahara T, Tasic B, Maniatis T, et al. (2005). "Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site". Mol. Cell. 18 (2): 245–51. doi:10.1016/j.molcel.2005.03.018. PMID 15837427.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bedford MT, Frankel A, Yaffe MB, et al. (2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains". J. Biol. Chem. 275 (21): 16030–6. doi:10.1074/jbc.M909368199. PMID 10748127.
• Chan DC, Bedford MT, Leder P (1996). "Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains". EMBO J. 15 (5): 1045–54. doi:10.1002/j.1460-2075.1996.tb00442.x. PMC 450002. PMID 8605874.