WBP1

WW domain-binding protein 1 is a protein that in humans is encoded by the WBP1 gene.[5][6]

WBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JMQ, 1K5R
Identifiers
Aliases	WBP1, WBP-1, WW domain binding protein 1
External IDs	OMIM: 606961 MGI: 104710 HomoloGene: 8267 GeneCards: WBP1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.1 Start 74,458,400 bp[1] End 74,460,891 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 83,119,044 bp[2] End 83,121,559 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • WW domain binding Cellular component • cellular component Biological process • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23559	22377
Ensembl	ENSG00000239779	ENSMUSG00000030035
UniProt	Q96G27	P97764
RefSeq (mRNA)	NM_012477	NM_001083922 NM_001083923 NM_016757
RefSeq (protein)	NP_036609	NP_001077391 NP_001077392 NP_058037
Location (UCSC)	Chr 2: 74.46 – 74.46 Mb	Chr 6: 83.12 – 83.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands.

This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by a conserved region: XPPXY motif. The function of this protein has not been determined.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000239779 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030035 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen HI, Sudol M (Sep 1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc Natl Acad Sci U S A. 92 (17): 7819–23. doi:10.1073/pnas.92.17.7819. PMC 41237. PMID 7644498.
6. "Entrez Gene: WBP1 WW domain binding protein 1".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ludes-Meyers JH, Kil H, Bednarek AK, et al. (2004). "WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins". Oncogene. 23 (29): 5049–55. doi:10.1038/sj.onc.1207680. PMC 4143251. PMID 15064722.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3: 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
• Chen HI, Einbond A, Kwak SJ, et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands". J. Biol. Chem. 272 (27): 17070–7. doi:10.1074/jbc.272.27.17070. PMID 9202023.
• Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.