VASH1

Vasohibin-1 is a protein that in humans is encoded by the VASH1 gene.[5]

VASH1
Identifiers
Aliases	VASH1, KIAA1036, vasohibin 1, TTCP 1
External IDs	OMIM: 609011 MGI: 2442543 HomoloGene: 8941 GeneCards: VASH1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 76,761,468 bp[1] End 76,783,015 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 D2 Start 86,678,700 bp[2] End 86,692,091 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • actin binding • metallocarboxypeptidase activity • carboxypeptidase activity • peptidase activity • hydrolase activity Cellular component • cytoplasm • extracellular region • apical part of cell • endoplasmic reticulum • extracellular Biological process • negative regulation of angiogenesis • regulation of cellular senescence • cell cycle • negative regulation of lymphangiogenesis • response to wounding • regulation of angiogenesis • negative regulation of blood vessel endothelial cell migration • cell cycle arrest • angiogenesis • negative regulation of endothelial cell migration • negative regulation of endothelial cell proliferation • placenta blood vessel development • labyrinthine layer blood vessel development • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22846	238328
Ensembl	ENSG00000071246	ENSMUSG00000021256
UniProt	Q7L8A9	Q8C1W1
RefSeq (mRNA)	NM_014909	NM_177354
RefSeq (protein)	NP_055724	NP_796328
Location (UCSC)	Chr 14: 76.76 – 76.78 Mb	Chr 12: 86.68 – 86.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000071246 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021256 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: VASH1 vasohibin 1".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
• Watanabe K, Hasegawa Y, Yamashita H, et al. (2004). "Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis". J. Clin. Invest. 114 (7): 898–907. doi:10.1172/JCI21152. PMC 518662. PMID 15467828.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shimizu K, Watanabe K, Yamashita H, et al. (2005). "Gene regulation of a novel angiogenesis inhibitor, vasohibin, in endothelial cells". Biochem. Biophys. Res. Commun. 327 (3): 700–6. doi:10.1016/j.bbrc.2004.12.073. PMID 15649403.
• Sonoda H, Ohta H, Watanabe K, et al. (2006). "Multiple processing forms and their biological activities of a novel angiogenesis inhibitor vasohibin". Biochem. Biophys. Res. Commun. 342 (2): 640–6. doi:10.1016/j.bbrc.2006.01.185. PMID 16488400.
• Yamashita H, Abe M, Watanabe K, et al. (2006). "Vasohibin prevents arterial neointimal formation through angiogenesis inhibition". Biochem. Biophys. Res. Commun. 345 (3): 919–25. doi:10.1016/j.bbrc.2006.04.176. PMID 16707096.