UXS1

UDP-glucuronic acid decarboxylase 1 is an enzyme that in humans is encoded by the UXS1 gene.[5][6]

UXS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B69, 4GLL, 4LK3, 4M55
Identifiers
Aliases	UXS1, SDR6E1, UGD, UDP-glucuronate decarboxylase 1
External IDs	OMIM: 609749 MGI: 1915133 HomoloGene: 41609 GeneCards: UXS1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.2 Start 106,093,303 bp[1] End 106,194,339 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C1.1 Start 43,746,966 bp[2] End 43,827,800 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • carboxy-lyase activity • NAD+ binding • lyase activity • UDP-glucuronate decarboxylase activity Cellular component • integral component of membrane • Golgi cisterna membrane • Golgi apparatus • extracellular exosome • mitochondrion • membrane • cytoplasm Biological process • protein tetramerization • UDP-D-xylose biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80146	67883
Ensembl	ENSG00000115652	ENSMUSG00000057363
UniProt	Q8NBZ7	Q91XL3
RefSeq (mRNA)	NM_001253875 NM_001253876 NM_025076 NM_001377504 NM_001377505 NM_001377506 NM_001377507 NM_001377508 NM_001377509	NM_026430
RefSeq (protein)	NP_001240804 NP_001240805 NP_079352 NP_001364433 NP_001364434 NP_001364435 NP_001364436 NP_001364437 NP_001364438	NP_080706 NP_001355216 NP_001355217 NP_001355218
Location (UCSC)	Chr 2: 106.09 – 106.19 Mb	Chr 1: 43.75 – 43.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

UDP-glucuronate decarboxylase (UGD; EC 4.1.1.35) catalyzes the formation of UDP-xylose from UDP-glucuronate. UDP-xylose is then used to initiate glycosaminoglycan biosynthesis on the core protein of proteoglycans.[supplied by OMIM][6]

See also

• Carboxy-lyases
• Golgi apparatus
• Tetrameric protein
• Uridine diphosphate (UDP)

References

1. GRCh38: Ensembl release 89: ENSG00000115652 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057363 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
6. "Entrez Gene: UXS1 UDP-glucuronate decarboxylase 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Moriarity JL, Hurt KJ, Resnick AC, et al. (2002). "UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization". J. Biol. Chem. 277 (19): 16968–75. doi:10.1074/jbc.M109316200. PMID 11877387.
• Hwang HY, Horvitz HR (2002). "The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14218–23. doi:10.1073/pnas.172522199. PMC 137864. PMID 12391314.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.