UAP1

UDP-N-acetylhexosamine pyrophosphorylase is an enzyme that in humans is encoded by the UAP1 gene.[5][6][7]

UAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JV1, 1JV3, 1JVD, 1JVG
Identifiers
Aliases	UAP1, AGX, AGX1, AGX2, SPAG2, UDP-N-acetylglucosamine pyrophosphorylase 1
External IDs	OMIM: 602862 MGI: 1334459 HomoloGene: 2342 GeneCards: UAP1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 162,561,506 bp[1] End 162,599,842 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 170,141,938 bp[2] End 170,174,957 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • uridylyltransferase activity • nucleotidyltransferase activity • carbohydrate binding • identical protein binding • UDP-N-acetylglucosamine diphosphorylase activity Cellular component • cell membrane • nucleoplasm • cytoplasm • cytosol Biological process • UDP-N-acetylglucosamine metabolic process • metabolism • UDP-N-acetylglucosamine biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6675	107652
Ensembl	ENSG00000117143	ENSMUSG00000026670
UniProt	Q16222	Q91YN5
RefSeq (mRNA)	NM_003115 NM_001324113 NM_001324114 NM_001324115 NM_001324116 NM_001324117	NM_133806 NM_001305045 NM_001305046
RefSeq (protein)	NP_001311042 NP_001311043 NP_001311044 NP_001311045 NP_001311046 NP_003106	NP_001291974 NP_001291975 NP_598567
Location (UCSC)	Chr 1: 162.56 – 162.6 Mb	Chr 1: 170.14 – 170.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000117143 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026670 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mio T, Yabe T, Arisawa M, Yamada-Okabe H (Jul 1998). "The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism". J Biol Chem. 273 (23): 14392–7. doi:10.1074/jbc.273.23.14392. PMID 9603950.
6. Diekman AB, Goldberg E (Aug 1994). "Characterization of a human antigen with sera from infertile patients". Biol Reprod. 50 (5): 1087–93. doi:10.1095/biolreprod50.5.1087. PMID 8025165.
7. "Entrez Gene: UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1".

Further reading

• Diekman AB, Olson G, Goldberg E (1998). "Expression of the human antigen SPAG2 in the testis and localization to the outer dense fibers in spermatozoa". Mol. Reprod. Dev. 50 (3): 284–93. doi:10.1002/(SICI)1098-2795(199807)50:3<284::AID-MRD4>3.0.CO;2-F. PMID 9621304.
• Wang-Gillam A, Pastuszak I, Elbein AD (1998). "A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc". J. Biol. Chem. 273 (42): 27055–7. doi:10.1074/jbc.273.42.27055. PMID 9765219.
• Peneff C, Ferrari P, Charrier V, et al. (2002). "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture". EMBO J. 20 (22): 6191–202. doi:10.1093/emboj/20.22.6191. PMC 125729. PMID 11707391.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.