Trimerelysin I
Trimerelysin I (EC 3.4.24.52, Trimeresurus metalloendopeptidase I, hemorrhagic proteinase HR1A, hemorrhagic metalloproteinase HR1A, metalloproteinase HR1A) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Cleavage of only two bonds His10-Leu and Ala14-Leu in the insulin B chain
| Trimerelysin I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.52 | ||||||||
| CAS number | 151125-16-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This endopeptidase is present in the venom of the habu snake (Trimeresurus flavoviridis).
References
- Omori-Satoh T, Sadahiro S (October 1979). "Resolution of the major hemorrhagic component of Trimeresurus flavoviridis venom into two parts". Biochimica et Biophysica Acta (BBA) - Protein Structure. 580 (2): 392–404. doi:10.1016/0005-2795(79)90151-x. PMID 518906.
- Yamakawa Y, Omori-Satoh T (1988). "The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis)". Toxicon. 26 (2): 227–31. doi:10.1016/0041-0101(88)90178-x. PMID 3284004.
- Takeya H, Oda K, Miyata T, Omori-Satoh T, Iwanaga S (September 1990). "The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis". The Journal of Biological Chemistry. 265 (27): 16068–73. PMID 2398046.
External links
- Trimerelysin+I at the US National Library of Medicine Medical Subject Headings (MeSH)
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