Transaldolase 1

Transaldolase 1 is a protein that in humans is encoded by the TALDO1 gene. [5]

TALDO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F05
Identifiers
Aliases	TALDO1, TAL, TAL-H, TALDOR, TALH, transaldolase 1
External IDs	OMIM: 602063 MGI: 1274789 HomoloGene: 4916 GeneCards: TALDO1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 747,415 bp[1] End 765,012 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 141,392,199 bp[2] End 141,402,968 bp[2]
Gene ontology Molecular function • transferase activity • sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity • catalytic activity • GO:0001948 protein binding • monosaccharide binding • carbohydrate binding Cellular component • cytoplasm • cytosol • extracellular exosome • intracellular membrane-bounded organelle • cell nucleus • nucleoplasm Biological process • fructose 6-phosphate metabolic process • pentose phosphate pathway • pentose-phosphate shunt, non-oxidative branch • xylulose biosynthetic process • glyceraldehyde-3-phosphate metabolic process • interleukin-12-mediated signaling pathway • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6888	21351
Ensembl	ENSG00000177156	ENSMUSG00000025503
UniProt	P37837	Q93092
RefSeq (mRNA)	NM_006755	NM_011528
RefSeq (protein)	NP_006746	NP_035658
Location (UCSC)	Chr 11: 0.75 – 0.77 Mb	Chr 7: 141.39 – 141.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008].

References

1. GRCh38: Ensembl release 89: ENSG00000177156 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025503 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Transaldolase 1". Retrieved 2017-10-19.

Further reading

• Grossman CE, Qian Y, Banki K, Perl A (2004). "ZNF143 mediates basal and tissue-specific expression of human transaldolase". J. Biol. Chem. 279 (13): 12190–205. doi:10.1074/jbc.M307039200. PMID 14702349.
• Huang JB, Espinoza J, Romero R, Petty HR (2005). "Transaldolase is part of a supramolecular complex containing glucose-6-phosphate dehydrogenase in human neutrophils that undergoes retrograde trafficking during pregnancy". Metab. Clin. Exp. 54 (8): 1027–33. doi:10.1016/j.metabol.2005.03.005. PMID 16092052.
• Valayannopoulos V, Verhoeven NM, Mention K, Salomons GS, Sommelet D, Gonzales M, Touati G, de Lonlay P, Jakobs C, Saudubray JM (2006). "Transaldolase deficiency: a new cause of hydrops fetalis and neonatal multi-organ disease". J. Pediatr. 149 (5): 713–7. doi:10.1016/j.jpeds.2006.08.016. PMID 17095351.
• Silberstein M, Landon MR, Wang YE, Perl A, Vajda S (2006). "Computational methods for functional site identification suggest a substrate access channel in transaldolase". Genome Inform. 17 (1): 13–22. PMID 17503352.
• Wamelink MM, Smith DE, Jansen EE, Verhoeven NM, Struys EA, Jakobs C (2007). "Detection of transaldolase deficiency by quantification of novel seven-carbon chain carbohydrate biomarkers in urine". J. Inherit. Metab. Dis. 30 (5): 735–42. doi:10.1007/s10545-007-0590-2. PMID 17603756.
• Wamelink MM, Struys EA, Salomons GS, Fowler D, Jakobs C, Clayton PT (2008). "Transaldolase deficiency in a two-year-old boy with cirrhosis". Mol. Genet. Metab. 94 (2): 255–8. doi:10.1016/j.ymgme.2008.01.011. PMID 18331807.
• Qian Y, Banerjee S, Grossman CE, Amidon W, Nagy G, Barcza M, Niland B, Karp DR, Middleton FA, Banki K, Perl A (2008). "Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing". Biochem. J. 415 (1): 123–34. doi:10.1042/BJ20080722. PMID 18498245.
• Schneider S, Sandalova T, Schneider G, Sprenger GA, Samland AK (2008). "Replacement of a phenylalanine by a tyrosine in the active site confers fructose-6-phosphate aldolase activity to the transaldolase of Escherichia coli and human origin". J. Biol. Chem. 283 (44): 30064–72. doi:10.1074/jbc.M803184200. PMC 2662071. PMID 18687684.
• Basta PV, Bensen JT, Tse CK, Perou CM, Sullivan PF, Olshan AF (2008). "Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neck". Cancer Detect. Prev. 32 (3): 200–8. doi:10.1016/j.cdp.2008.08.008. PMC 2614275. PMID 18805652.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.