Teratocarcinoma-derived growth factor 1

Teratocarcinoma-derived growth factor 1 is a protein that in humans is encoded by the TDGF1 gene.[5][6] The protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants.[7]

TDGF1
Identifiers
Aliases	TDGF1, CR, CRGF, CRIPTO, teratocarcinoma-derived growth factor 1, CR-1
External IDs	MGI: 98658 HomoloGene: 2416 GeneCards: TDGF1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 46,574,534 bp[1] End 46,582,457 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F2|9 60.79 cM Start 110,939,603 bp[2] End 110,946,158 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • growth factor activity • receptor binding • nodal binding • activin receptor binding Cellular component • membrane • cell membrane • cell surface • apical plasma membrane • membrane raft • anchored component of membrane • extrinsic component of plasma membrane • extracellular • extracellular region Biological process • cell differentiation • cellular response to interleukin-6 • epidermal growth factor receptor signaling pathway • somatic stem cell population maintenance • positive regulation of cell migration • cellular response to hepatocyte growth factor stimulus • cellular response to tumor necrosis factor • negative regulation of apoptotic process • cellular response to fibroblast growth factor stimulus • morphogenesis of a branching structure • cell migration involved in sprouting angiogenesis • mammary gland development • positive regulation of endothelial cell migration • cellular response to epidermal growth factor stimulus • heart development • activation of MAPK activity • regulation of signal transduction • peptidyl-serine phosphorylation • positive regulation of cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • cellular response to interferon-gamma • anterior/posterior axis specification, embryo • regulation of receptor activity • embryo development ending in birth or egg hatching • determination of left/right symmetry • anterior/posterior pattern specification • BMP signaling pathway • nodal signaling pathway • anatomical structure development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6997	21667
Ensembl	ENSG00000241186	ENSMUSG00000032494
UniProt	P13385	P51865
RefSeq (mRNA)	NM_003212 NM_001174136	NM_011562
RefSeq (protein)	NP_001167607 NP_003203	n/a
Location (UCSC)	Chr 3: 46.57 – 46.58 Mb	Chr 9: 110.94 – 110.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000241186 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032494 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dono R, Montuori N, Rocchi M, De Ponti-Zilli L, Ciccodicola A, Persico MG (Oct 1991). "Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence". Am J Hum Genet. 49 (3): 555–65. PMC 1683146. PMID 1882841.
6. Scognamiglio B, Baldassarre G, Cassano C, Tucci M, Montuori N, Dono R, Lembo G, Barra A, Lago CT, Viglietto G, Rocchi M, Persico MG (Jul 1999). "Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1". Cytogenet Cell Genet. 84 (3–4): 220–4. doi:10.1159/000015263. PMID 10393436.
7. "Entrez Gene: TDGF1 teratocarcinoma-derived growth factor 1".

Further reading

• Salomon DS, Bianco C, De Santis M (1999). "Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia". BioEssays. 21 (1): 61–70. doi:10.1002/(SICI)1521-1878(199901)21:1<61::AID-BIES8>3.0.CO;2-H. PMID 10070255.
• Adamson ED, Minchiotti G, Salomon DS (2002). "Cripto: a tumor growth factor and more". J. Cell. Physiol. 190 (3): 267–78. doi:10.1002/jcp.10072. PMID 11857442.
• Ciccodicola A, Dono R, Obici S, et al. (1989). "Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells". EMBO J. 8 (7): 1987–91. PMC 401069. PMID 2792079.
• Saccone S, Rapisarda A, Motta S, et al. (1995). "Regional localization of the human EGF-like growth factor CRIPTO gene (TDGF-1) to chromosome 3p21". Hum. Genet. 95 (2): 229–30. doi:10.1007/BF00209409. PMID 7860072.
• Brandt R, Normanno N, Gullick WJ, et al. (1994). "Identification and biological characterization of an epidermal growth factor-related protein: cripto-1". J. Biol. Chem. 269 (25): 17320–8. PMID 8006041.
• Friess H, Yamanaka Y, Büchler M, et al. (1994). "Cripto, a member of the epidermal growth factor family, is over-expressed in human pancreatic cancer and chronic pancreatitis". Int. J. Cancer. 56 (5): 668–74. doi:10.1002/ijc.2910560511. PMID 8314343.
• Panico L, D'Antonio A, Salvatore G, et al. (1996). "Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues". Int. J. Cancer. 65 (1): 51–6. doi:10.1002/(SICI)1097-0215(19960103)65:1<51::AID-IJC9>3.0.CO;2-0. PMID 8543395.
• Kannan S, De Santis M, Lohmeyer M, et al. (1997). "Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells". J. Biol. Chem. 272 (6): 3330–5. doi:10.1074/jbc.272.6.3330. PMID 9013573.
• Xu C, Liguori G, Adamson ED, Persico MG (1998). "Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1". Dev. Biol. 196 (2): 237–47. doi:10.1006/dbio.1998.8862. PMID 9576836.
• Xu C, Liguori G, Persico MG, Adamson ED (1999). "Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes". Development. 126 (3): 483–94. PMID 9876177.
• Ebert AD, Wechselberger C, Frank S, et al. (1999). "Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells". Cancer Res. 59 (18): 4502–5. PMID 10493495.
• Reissmann E, Jörnvall H, Blokzijl A, et al. (2001). "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development". Genes Dev. 15 (15): 2010–22. doi:10.1101/gad.201801. PMC 312747. PMID 11485994.
• Bianco C, Adkins HB, Wechselberger C, et al. (2002). "Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells". Mol. Cell. Biol. 22 (8): 2586–97. doi:10.1128/MCB.22.8.2586-2597.2002. PMC 133714. PMID 11909953.
• Yan YT, Liu JJ, Luo Y, et al. (2002). "Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway". Mol. Cell. Biol. 22 (13): 4439–49. doi:10.1128/MCB.22.13.4439-4449.2002. PMC 133918. PMID 12052855.
• de la Cruz JM, Bamford RN, Burdine RD, et al. (2002). "A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defects". Hum. Genet. 110 (5): 422–8. doi:10.1007/s00439-002-0709-3. PMID 12073012.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.